Pilagan Eye Drop
Pilocarpine Hydrochloride
2%
Abbott India Ltd.
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Indications
Pilagan Eye Drop is used for:
Dry mouth, Sjogren's syndrome
Adult Dose
Oral
Dry mouth after radiotherapy for malignant neoplasms of the head and neck
Adult: Initially, 5 mg tid. If necessary, increase dose gradually after 4 wk until adequate response is achieved. Max: 10 mg tid.
Hepatic impairment: Reduce dose in moderate to severe cirrhosis.
Oral
Sjogren's syndrome
Adult: For dry eyes and mouth: 5 mg 4 times daily. Max: 30 mg daily. Stop treatment if no improvement after 3 mth.
Hepatic impairment: Reduce dose in moderate to severe cirrhosis.
Child Dose
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Angle-closure glaucoma; acute iritis, anterior uveitis; hypersensitivity. Pregnancy.
Precautions
CVD, cholelithiasis, biliary tract dz, COPD, chronic bronchitis, concomitant use of beta adrenergic agonist, renal insufficiency, PUD, Parkinson's, hyperthyroidism, urinary tract obstruction
Lactation: unknown if drug is distributed into breast milk; use caution
Pregnancy-Lactation
Interactions
Concomitant admin of 2 miotics may increase risk of toxic reactions. Aminoglycosides, clindamycin, colistin, cyclopropane and halogenated inhalational anaesthetics, quinine, procainamide, lithium and beta-blockers may reduce the efficacy of pilacarpine. Concurrent use with beta-blockers may lead to bradycardia. May prolong the action of suxamethonium.
Potentially Fatal: Miotic and ocular hypotensive effect antagonised by anticholinergics. Conduction disturbances with beta-blockers.
Adverse Effects
Side effects of Pilocarpine Hydrochloride :
>10%
Sweating (29%),Headache (15%),Flushing (8-13%),Chills (3-15%)
1-10%
Nervousness (10%),Nausea (6%),Dizziness (>3%),Asthenia (>3%)
Frequency Not Defined
Confusion,Hypotension,Hypertension,Bradycardia,Tachycardia,Increased airway resistance,Abdominal cramping,Diarrhea,Urinary frequency,Bladder tightness,Decreased visual acuity
Mechanism of Action
Pilocarpine is a tertiary parasympathomimetic that directly stimulates cholinergic receptors in the eyes causing pupillary constriction, spasm of accommodation and a transient rise in IOP followed by a fall.
Note
Pilagan 2% Eye Drop manufactured by Abbott India Ltd.. Its generic name is Pilocarpine Hydrochloride. Pilagan is availble in Nepal.
Farmaco Nepal drug index information on Pilagan Eye Drop is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.