Pipzo Injection
Piperacillin + Tazobactam
4000mg + 500mg
Alkem Laboratories Ltd.
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| Retail Price | 412.19 NPR |
Available as:
Indications
Pipzo Injection is used for:
Septicaemia, Nosocomial pneumonia
Adult Dose
Intravenous
Nosocomial pneumonia
Adult: Each vial contains 4.5 g (piperacillin 4 g and tazobactam 0.5 g): 4.5 g 6 hrly for 5-14 days by infusion over 30 min. When used empirically, combination w/ aminoglycoside or antipseudomonal fluoroquinolone is recommended.
Empiric therapy for febrile neutropenic patients
Adult: Each vial contains 4.5 g (piperacillin 4 g and tazobactam 0.5 g): 4.5 g 6 hrly for 5-14 days by infusion over 30 min.
Complicated intra-abdominal infections
Adult: Each vial contains 4.5 g (piperacillin 4 g and tazobactam 0.5 g): 4.5 g 8 hrly for 5-14 days by infusion over 30 min.
Complicated urinary tract infections; Skin and soft tissue infections
Adult: Each vial contains 4.5 g (piperacillin 4 g and tazobactam 0.5 g): 4.5 g 8 hrly for 5-14 days by infusion over 30 min.
Child Dose
Intravenous
Child: Usually <40 kg: 240–300 mg PIP/kg/day 8 hourly
Alternatively
Nosocomial pneumonia
Child: 2-12 yr 90 mg/kg (piperacillin 80 mg/kg and tazobactam 10 mg/kg) 6 hrly for 5-14 days by infusion over 30 min.
Max: 4.5 g per dose; >12 yr Same as adult dose.
Empiric therapy for febrile neutropenic patients
Child: 2-12 yr 90 mg/kg (piperacillin 80 mg/kg and tazobactam 10 mg/kg) 6 hrly for 5-14 days by infusion over 30 min.
Max: 4.5 g per dose; >12 yr Same as adult dose.
Complicated intra-abdominal infections
Child: 2-12 yr 112.5 mg/kg (piperacillin 100 mg and tazobactam 12.5 mg) 8 hrly for 5-14 days by infusion over 30 min.
Max: 4.5 g per dose.
Renal Dose
Renal impairment: Haemodialysis patients: 2.25 g 12 hrly; additional dose of 0.75 g after each dialysis session. CAPD: 2.25 g 12 hrly.
CrCl (ml/min) Dosage Recommendation
<20 2.25 g 8 hrly.
20-40 2.25 g 6 hrly.
Administration
Reconstitution
Reconstitute initially (2.25 g in 10 mL, 4.5 g in 20 mL) w/ water for inj, glucose 5% or NaCl 0.9%, then further dilute to 50-150 mL w/ compatible infusion soln.
IV Administration
Infusion over 30 min
Contra Indications
Hypersensitivity.
Precautions
Pregnancy and lactation, pseudomembranous colitis. Assess hematopoietic function periodically. Perform periodic electrolyte determinations in patients with low K reserves. Increased risk of fever and rash in patients with cystic fibrosis. Increased risk of bleeding manifestations. Prolonged treatment may increase risk of superinfections. Convulsions or neuromuscular excitability may occur when high doses are used, especially in renally impaired patients. Renal impairment.
Lactation: Low concentrations of piperacillin excreted in breast milk; tazobactam unknown; use caution
Pregnancy-Lactation
Interactions
Interacts w/ high doses of heparin, oral anticoagulants or other drugs that affect blood coagulation or thrombocyte function. Prolongs the neuromuscular blockade of vecuronium and non-depolarising muscle relaxants. Prolongs half-lives w/ probenecid. Increased risk of methotrexate toxicity.
Adverse Effects
Side effects of Piperacillin + Tazobactam :
>10%
Diarrhea (7-11%)
1-10%
Constipation (1-8%),Headache (1-8%),Insomnia (4-7%),Nausea (2-7%),Fever (2-5%),Oral candidiasis (2-4%),Rash (2-4%),Vomiting (2-4%),Dyspepsia (3%),Pruritus (3%),Pain (2-3%),Hypertension (2%),Leukopenia (1%),Thrombocytopenia (1.4%)
<1%
Anaphylaxis,Agranulocytosis,Thrombocytopenia,Eosinophilia,Leukopenia,Positive Coombs test,Prolonged PT and PTT,Transient LFT and creatinine elevations.Seizure,Pulmonary edema,Pulmonary embolism
Mechanism of Action
Piperacillin has an antimicrobial activity against a wide range of gm-ve organisms including K. pneumoniae, P. aeruginosa, Enterobacteriaceae and against gm+ve organisms eg E. faecalis and B. fragilis. Tazobactam is a penicillanic acid sulfone derivative with beta-lactamase inhibitory properties. In combination, tazobactam enhances the activity of piperacillin against beta-lactamase-producing bacteria.
Note
Pipzo 4000mg + 500mg Injection manufactured by Alkem Laboratories Ltd.. Its generic name is Piperacillin + Tazobactam. Pipzo is availble in Nepal.
Farmaco Nepal drug index information on Pipzo Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.