Practin Syrup

Cyproheptadine HCI
2mg
Wockhardt Ltd.
Pack size 1
Dispensing mode
Source
Agent
Retail Price 109.60 NPR

Indications

Practin Syrup is used for: Rash and pruritus in a variety of condition; appetite stimulation , anorexia nervosa ; cushing's and Nelson's syndrome, acromegaly and hyperprolactinemia ; migraine; antidepressant-induced inorgasmia .

Adult Dose

Oral Allergic conditions Adult: Initially, 4 mg tid, adjusted as necessary. Usual: 12-16 mg daily in 3-4 divided doses. Max: 32 mg/day. Treatment and prophylaxis of migraine and other vascular headaches Adult: 4 mg may be repeated after 30 min. Not to exceed 8 mg w/in a 4- to 6-hr period. Maintenance: 4 mg 4-6 hrly.

Child Dose

Oral Allergic conditions Child: 2-6 yr 2 mg bid or tid. Max: 12 mg daily; 7-14 yr 4 mg bid or tid. Max: 16 mg daily. Migraine Prophylaxis < 3 years: Safety and efficacy not established >3 years and adolescents: 0.2-0.4 mg/kg/day PO divided BID; not to exceed 0.5 mg/kg/day

Renal Dose

Administration

May be taken with or without food. May be taken w/ meals to reduce GI discomfort.

Contra Indications

Narrow-angle glaucoma; acute asthmatic attack; bladder neck obstruction; stenosing peptic ulcer; GIT obstruction; MAOIs therapy; hypersensitivity; neonates, lactation.

Precautions

Elderly; epilepsy; tasks requiring mental alertness; symptomatic prostate hypertrophy; epilepsy; alcoholism; pregnancy. Lactation: Excretion in milk unknown; contraindicated

Pregnancy-Lactation

Interactions

May have additive effects w/ CNS depressants e.g. hypnotics, sedatives, tranquilizers, antianxiety agents. Potentially Fatal: MAOIs prolong and intensify the anticholinergic effects of antihistamines.

Adverse Effects

Side effects of Cyproheptadine HCI : Psychiatric/neurologic: CNS depression, drowsiness, sedation ranging from mild drowsiness to deep sleep (most frequent), dizziness, lassitude, disturbed coordination; less commonly, restlessness, insomnia, tremors, euphoria, nervousness, irritability, delirium, seizures, toxic psychosis, paresthesia Muscular: Weakness Cardiovascular: Palpitation, tachycardia, palpitation, ECG changes (eg, widened QRS), arrhythmias (eg, extrasystole, heart block), hypotension, hypertension, dizziness, sedation, hypotension GI: Epigastric distress, anorexia, nausea, vomiting, diarrhea, constipation Hepatic: Cholestasis, hepatitis, hepatic failure, hepatic function abnormality, jaundice (rare) Skin: Eczema, pruritus, inflammation, papular rash, erythema on exposed skin Sensory: Visual disturbances, blurred vision, diplopia, tinnitus, acute labyrinthitis Renal: Dysuria, urinary retention Respiratory: Thickening of bronchial secretions, wheezing, nasal stuffiness Other: Vertigo, sweating, chills, early menses, headache, impotence, dryness of mouth, nose, and throat, facial dyskinesia, tightness of chest, faintness

Mechanism of Action

Cyproheptadine is a sedating antihistamine w/ antimuscarinic, serotonin antagonist and Ca channel blocking properties. It competes w/ histamine for H1-receptor sites on effector cells in the GI tract, blood vessels and resp tract.

Note

Practin 2mg Syrup manufactured by Wockhardt Ltd.. Its generic name is Cyproheptadine HCI. Practin is availble in Nepal. Farmaco Nepal drug index information on Practin Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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