Practin Syrup
Cyproheptadine HCI
2mg
Wockhardt Ltd.
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 109.60 NPR |
Available as:
Indications
Practin Syrup is used for:
Rash and pruritus in a variety of condition; appetite stimulation , anorexia nervosa ; cushing's and Nelson's syndrome, acromegaly and hyperprolactinemia ; migraine; antidepressant-induced inorgasmia .
Adult Dose
Oral
Allergic conditions
Adult: Initially, 4 mg tid, adjusted as necessary. Usual: 12-16 mg daily in 3-4 divided doses. Max: 32 mg/day.
Treatment and prophylaxis of migraine and other vascular headaches
Adult: 4 mg may be repeated after 30 min. Not to exceed 8 mg w/in a 4- to 6-hr period. Maintenance: 4 mg 4-6 hrly.
Child Dose
Oral
Allergic conditions
Child: 2-6 yr 2 mg bid or tid. Max: 12 mg daily;
7-14 yr 4 mg bid or tid. Max: 16 mg daily.
Migraine
Prophylaxis
< 3 years: Safety and efficacy not established
>3 years and adolescents: 0.2-0.4 mg/kg/day PO divided BID; not to exceed 0.5 mg/kg/day
Renal Dose
Administration
May be taken with or without food. May be taken w/ meals to reduce GI discomfort.
Contra Indications
Narrow-angle glaucoma; acute asthmatic attack; bladder neck obstruction; stenosing peptic ulcer; GIT obstruction; MAOIs therapy; hypersensitivity; neonates, lactation.
Precautions
Elderly; epilepsy; tasks requiring mental alertness; symptomatic prostate hypertrophy; epilepsy; alcoholism; pregnancy.
Lactation: Excretion in milk unknown; contraindicated
Pregnancy-Lactation
Interactions
May have additive effects w/ CNS depressants e.g. hypnotics, sedatives, tranquilizers, antianxiety agents.
Potentially Fatal: MAOIs prolong and intensify the anticholinergic effects of antihistamines.
Adverse Effects
Side effects of Cyproheptadine HCI :
Psychiatric/neurologic: CNS depression, drowsiness, sedation ranging from mild drowsiness to deep sleep (most frequent), dizziness, lassitude, disturbed coordination; less commonly, restlessness, insomnia, tremors, euphoria, nervousness, irritability, delirium, seizures, toxic psychosis, paresthesia
Muscular: Weakness
Cardiovascular: Palpitation, tachycardia, palpitation, ECG changes (eg, widened QRS), arrhythmias (eg, extrasystole, heart block), hypotension, hypertension, dizziness, sedation, hypotension
GI: Epigastric distress, anorexia, nausea, vomiting, diarrhea, constipation
Hepatic: Cholestasis, hepatitis, hepatic failure, hepatic function abnormality, jaundice (rare)
Skin: Eczema, pruritus, inflammation, papular rash, erythema on exposed skin
Sensory: Visual disturbances, blurred vision, diplopia, tinnitus, acute labyrinthitis
Renal: Dysuria, urinary retention
Respiratory: Thickening of bronchial secretions, wheezing, nasal stuffiness
Other: Vertigo, sweating, chills, early menses, headache, impotence, dryness of mouth, nose, and throat, facial dyskinesia, tightness of chest, faintness
Mechanism of Action
Cyproheptadine is a sedating antihistamine w/ antimuscarinic, serotonin antagonist and Ca channel blocking properties. It competes w/ histamine for H1-receptor sites on effector cells in the GI tract, blood vessels and resp tract.
Note
Practin 2mg Syrup manufactured by Wockhardt Ltd.. Its generic name is Cyproheptadine HCI. Practin is availble in Nepal.
Farmaco Nepal drug index information on Practin Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.