Prax 10 Tablet
Prasugrel
10mg
Torrent Pharmaceuticals Ltd.
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Indications
Prax 10 Tablet is used for:
Acute coronary syndromes, thrombotic cardiovascular (CV) events, stent thrombosis, unstable angina (UA) or non-ST-elevation myocardial infarction (NSTEMI), ST-elevation myocardial infarction (STEMI), Stroke
Adult Dose
Oral
Acute coronary syndrome
Adult: 60 mg as loading dose, followed by 10 mg once daily for up to 12 mth, given in combination w/ aspirin.
Elderly: >75 yr Maintenance: 5 mg once daily.
Patient w/ low body wt (<60 kg): 5 mg once daily as maintenance dose.
Hepatic impairment: Severe (Child-Pugh class C): Contraindicated.
Child Dose
Renal Dose
Renal impairment
Dose adjustment not necessary
Administration
May be taken with or without food.
Contra Indications
Active pathological bleeding such as peptic ulcer or intracranial hamorrhage. Patient with a history of prior transient ischemic attack or stroke
Precautions
Patient w/ propensity to bleed, low body wt (<60 kg). Patient who will undergo CABG and other surgical procedure; coronary angiography in UA/NSTEMI patients. Elderly (>75 yr). Pregnancy and lactation. Monitoring Parameters Monitor Hb and haematocrit periodically; may consider platelet function testing.
Pregnancy-Lactation
Interactions
Increased risk of bleeding w/ oral anticoagulants (e.g. warfain), clopidogrel, NSAIDs and fibrinolytics.
Adverse Effects
Side effects of Prasugrel :
1-10%
Bleeding,Anemia,Atrial fibrillation,Back pain,Bradycardia,Dizziness,Dyspnea,Headache,Hypertension,Nausea
<1%
Thrombotic thrombocytopenic purpura,Abnormal hepatic function,Angioedema,Hematoma,Hemolysis,Hemorrhage,Abnormal liver function
Mechanism of Action
Prasugrel is a prodrug that inhibits platelet activation and aggregation. The active metabolite irreversibly blocks the P2Y12 component of adenosine diphosphate (ADP) receptors on the platelet, which prevents activation of the GPIIb/IIIa receptor complex, thereby reducing platelet activation and aggregation.
Note
Prax 10 10mg Tablet manufactured by Torrent Pharmaceuticals Ltd.. Its generic name is Prasugrel. Prax 10 is availble in Nepal.
Farmaco Nepal drug index information on Prax 10 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.