Premarin Tablet
Conjugated Oestrogens
0.625mg
Pfizer Ltd.
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| Retail Price | 40.24 NPR |
Available as:
Indications
Premarin Tablet is used for:
Osteoporosis, Fungal infections, Itching, Burning, Hot flashes, Vaginal dryness, Vaginal atrophy, Menopausal symptoms, Female hypogonadism, Metastatic breast carcinoma, Ovarian failure, Prostate carcinoma, Primary ovarian failure, Hormone replacement therapy, Oral contraceptives
Adult Dose
Menopausal Vasomotor Symptoms, Atrophic Vaginitis/Kraurosis Vulvae
0.3 mg PO once daily in either continuous daily regimen or cyclic regimen (25 days on, 5 days off); adjusted PRN; use lowest dose that control symptoms; may be given daily if medical assessment warrants it
Female Hypogonadism
0.3-0.625 mg PO once daily in cyclic regimen (3 weeks on, 1 week off); may be titrated every 6-12 months; adjusted PRN; add progestin treatment should be added to maintain bone mineral density once skeletal maturity achieved
Osteoporosis
Prophylaxis
0.3 mg PO once daily in cyclic regimen (25 days on, 5 days off); adjusted PRN based on clinical response; may be given daily if medical assessment warrants it; administer lowest effective dose
May also be used in combination with medroxyprogesterone acetate
Prostate Cancer
Palliation only
1.25-2.5 mg PO q8hr
Female Castration/Primary Ovarian Failure
1.25 mg PO once daily in cyclic regimen (25 days on, 5 days off); adjusted PRN; administer lowest effective dose
Breast Cancer Palliation
Metastatic disease in selected patients (males and females):10 mg PO q8hr for >3 months
Abnormal Uterine Bleeding
25 mg IV/IM; repeated in 6-12 hours PRN or 25 mg IV repeated q4hr for 24 hr; if no response after 2 doses, re-evaluate therapy
Alternative regimen: 10-20 mg/day PO divided q4hr
May administer low dose medroxyprogesterone acetate with therapy or following therapy
Cyclic therapy: 25 days on, 5 days off; either 3 weeks on, 1 week off
Child Dose
Renal Dose
Administration
Contra Indications
Severe liver impairment; breast carcinoma; thromboembolic disorders; CV disease; undiagnosed vag bleeding; estrogen-dependent neoplasms; hypersensitivity; pregnancy.
Precautions
Asthma, epilepsy, migraine; heart or kidney dysfunction; CV disease; cerebrovascular disorders; diabetes, hypercalcaemia; gall bladder disease; porphyria. Childn. Lactation.
Lactation: Use controversial; estrogens are excreted into breast milk in small quantities; use with caution
Pregnancy-Lactation
Interactions
Rifampicin, barbiturates increase rate of metabolism.
Potentially Fatal: May reduce the efficacy of anticoagulants.
Adverse Effects
Side effects of Conjugated Oestrogens :
>10%
Abdominal pain (15-17%),Back pain (13-14%),Breast enlargement,Breast tenderness (7-12%),Headache (26-32%),Arthralgia (7-14%),Pharyngitis (10-12%),Sinusitis (6-11%),Diarrhea (6-7%)
1-10%
Depression (5-8%),Dizziness (4-6%),Nervousness (2-5%),Flatulence (6-7%),Vaginitis (5-7%),Leukorrhea (4-7%),Leg cramps (3-7%),Increased cough (4-7%),Pruritus (4-5%)
Frequency Not Defined
Amenorrhea,Breakthrough bleeding,Corneal curvation change,Melasma,Spotting,Vaginal moniliasis,Weight changes
Potentially Fatal: Unopposed replacement therapy in postmenopausal women associated with increased risk of endometrial and breast cancer.
Potentially Fatal: Unopposed replacement therapy in postmenopausal women associated with increased risk of endometrial and breast cancer.
Mechanism of Action
Estrogens modulate pituitary secretion of gonadotropins, leutinising hormones and follicle-stimulating hormones through -ve feedback mechanism, thus reducing elevated levels of hormones in postmenopausal women during oestrogen replacement therapy.
Note
Premarin 0.625mg Tablet manufactured by Pfizer Ltd.. Its generic name is Conjugated Oestrogens. Premarin is availble in Nepal.
Farmaco Nepal drug index information on Premarin Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.