Pronor 5 Tablet

Finasteride
5mg
Square Pharmaceuticals Ltd.
Pack size 10's Pack
Dispensing mode
Source
Agent
Retail Price 21.75 NPR

Indications

Pronor 5 Tablet is used for: Male pattern baldness, Benign prostatic hyperplasia

Adult Dose

Oral Benign prostatic hyperplasia Adult: 5 mg once daily for at least 6 mth. Male pattern baldness Adult: 1 mg once daily for at least 3 mth. Hepatic impairment: Caution in liver dysfunction; monitor

Child Dose

Renal Dose

Renal impairment: Dose adjustment not necessary

Administration

May be taken with or without food.

Contra Indications

Children, exposure of pregnant women to finasteride either via direct contact with crushed tab or through semen of male sexual partners who are taking finasteride; pregnancy, lactation.

Precautions

Undiagnosed prostate cancer, liver dysfunction, obstructive uropathy. Lactation: Excretion in milk unknown; contraindicated

Pregnancy-Lactation

Interactions

No drug interactions of clinical importance have been identified. Finasteride does not appear to affect significantly the cytochrome P-450-linked drug metabolizing enzyme system. Compounds which have been tested in man have included propranolol, digoxin, glyburide, warfarin, theophylline and antipyrine, and no clinically meaningful interactions were found. Other Concomitant Therapy: Although specific interaction studies were not performed, in clinical studies Finasteride was used concomitantly with angiotensin converting-enzyme (ACE) inhibitors, acetaminophen, acetylsalicylic acid, alpha-blockers, beta-blockers, calcium-channel blockers, cardiac nitrates, diuretics, H2-antagonists, HMG-CoA reductase inhibitors, nonsteroidal anti-inflammatory drugs (NSAIDs), quinolones and benzodiazepines without evidence of clinically significant adverse interactions.

Adverse Effects

Side effects of Finasteride : 1-10% Erectile dysfunction (1.3-8.1%),Decrease libido (1.8-6.4%),Breast enlargement (0.5-1.8%),Ejaculation disorder (0.8-1.2%) <1% Breast tenderness (0.4-0.7%),Rash (0.5%)

Mechanism of Action

Finasteride is a competitive inhibitor of the enzyme 5-alpha reductase which converts testosterone to dihydrotestosterone (DHT), thus resulting in decreased serum levels of DHT.

Note

Pronor 5 5mg Tablet manufactured by Square Pharmaceuticals Ltd.. Its generic name is Finasteride. Pronor 5 is availble in Nepal. Farmaco Nepal drug index information on Pronor 5 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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