Prostodin 125 Injection
Carboprost
125mcg
Astra Zeneca
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Available as:
Indications
Prostodin 125 Injection is used for:
Pregnancy termination in the 2nd trimester (Abortion), Postpartum Uterine Bleeding
Adult Dose
Intramuscular
Pregnancy termination in the 2nd trimester/Abortion
Adult: Initially, 250 mcg. Alternatively, initiate w/ test dose of 100 mcg. May be repeated at 1.5- to 3.5-hr intervals depending on uterine response. May be increased to 500 mcg if uterine contractility is inadequate.
Max: 12 mg. Max duration: 2 days.
Intramuscular
Postpartum haemorrhage
Adult: Initially, 250 mcg by deep inj. May be repeated every 15-90-min. Max: 2 mg.
Child Dose
Renal Dose
Administration
Contra Indications
Acute pelvic inflammatory disease; active cardiac, pulmonary, renal or hepatic disease.
Precautions
History of glaucoma or raised IOP
Asthma, hypertension/hypotension, cardiovascular disease
Transient fever observed with treatment possibly as a result of carboprost's effect on hypothalamic thermoregulation
Caution in patients with anemia, jaundice, renal impairment, hepatic impairment diabetes or epilepsy
To decrease GI side effects pretreatment or concomitant use with antiemetic and antidiarrheal agents recommended
Not for IV
Rare cases of cardiovascular collapse reported with prostaglandins
Lactation: Excretion in milk unknown
Pregnancy-Lactation
Interactions
May potentiate effect of other oxytocics.
Adverse Effects
Side effects of Carboprost :
Nausea (1/3 patients), Vomiting (~2/3 patients),Diarrhea (~2/3 patients)
Nervousness,Epistaxis,Sleep disorder,Hyperthermia,Flushing,Asthma,Wheezing,Coughing,Chest pain,Hypertension,Syncope,Palpation,Tachycardia,Chest tightness,Anxiety,Chills/shivering,Dizziness,Drowsiness,Dystonia,Faintness,Headache,Lethargy,Lightheadedness,Vertigo,Rash,Breast tenderness,Dysmenorrhea-like pain,Hot flashes,Dry throat.Taste alterations,Uterine bleeding (excessive)
Local: injection site pain
Backache,Leg cramps,Muscular pain,Parethesia,Blurred vision,Eye pain,Eyelid twitching,Tinnitus,Bronchospasm,Dyspnea,Hiccups
Mechanism of Action
Carboprost, a synthetic analogue of naturally occurring prostaglandin F2α, stimulates uterine contractility, resulting in expulsion of the products of conception. It is also used to induce abortion between 13-20 wk of pregnancy. It produces myometrial contractions responsible for placental haemostasis.
Note
Prostodin 125 125mcg Injection manufactured by Astra Zeneca. Its generic name is Carboprost. Prostodin 125 is availble in Nepal.
Farmaco Nepal drug index information on Prostodin 125 Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.