Prostodin 125 Injection

Carboprost
125mcg
Astra Zeneca
Pack size 1
Dispensing mode
Source
Agent
Retail Price

Indications

Prostodin 125 Injection is used for: Pregnancy termination in the 2nd trimester (Abortion), Postpartum Uterine Bleeding

Adult Dose

Intramuscular Pregnancy termination in the 2nd trimester/Abortion Adult: Initially, 250 mcg. Alternatively, initiate w/ test dose of 100 mcg. May be repeated at 1.5- to 3.5-hr intervals depending on uterine response. May be increased to 500 mcg if uterine contractility is inadequate. Max: 12 mg. Max duration: 2 days. Intramuscular Postpartum haemorrhage Adult: Initially, 250 mcg by deep inj. May be repeated every 15-90-min. Max: 2 mg.

Child Dose

Renal Dose

Administration

Contra Indications

Acute pelvic inflammatory disease; active cardiac, pulmonary, renal or hepatic disease.

Precautions

History of glaucoma or raised IOP Asthma, hypertension/hypotension, cardiovascular disease Transient fever observed with treatment possibly as a result of carboprost's effect on hypothalamic thermoregulation Caution in patients with anemia, jaundice, renal impairment, hepatic impairment diabetes or epilepsy To decrease GI side effects pretreatment or concomitant use with antiemetic and antidiarrheal agents recommended Not for IV Rare cases of cardiovascular collapse reported with prostaglandins Lactation: Excretion in milk unknown

Pregnancy-Lactation

Interactions

May potentiate effect of other oxytocics.

Adverse Effects

Side effects of Carboprost : Nausea (1/3 patients), Vomiting (~2/3 patients),Diarrhea (~2/3 patients) Nervousness,Epistaxis,Sleep disorder,Hyperthermia,Flushing,Asthma,Wheezing,Coughing,Chest pain,Hypertension,Syncope,Palpation,Tachycardia,Chest tightness,Anxiety,Chills/shivering,Dizziness,Drowsiness,Dystonia,Faintness,Headache,Lethargy,Lightheadedness,Vertigo,Rash,Breast tenderness,Dysmenorrhea-like pain,Hot flashes,Dry throat.Taste alterations,Uterine bleeding (excessive) Local: injection site pain Backache,Leg cramps,Muscular pain,Parethesia,Blurred vision,Eye pain,Eyelid twitching,Tinnitus,Bronchospasm,Dyspnea,Hiccups

Mechanism of Action

Carboprost, a synthetic analogue of naturally occurring prostaglandin F2α, stimulates uterine contractility, resulting in expulsion of the products of conception. It is also used to induce abortion between 13-20 wk of pregnancy. It produces myometrial contractions responsible for placental haemostasis.

Note

Prostodin 125 125mcg Injection manufactured by Astra Zeneca. Its generic name is Carboprost. Prostodin 125 is availble in Nepal. Farmaco Nepal drug index information on Prostodin 125 Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Carboprost :