Proxcef D-SY
Cefpodoxime
Nepal Pharmaceuticals Pvt. Ltd.
| Pack size | 30ml |
|---|---|
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Available as:
Indications
Proxcef D-SY is used for:
Pharyngitis, Acute otitis media, Community-acquired pneumonia, Sinusitis, UTI, Cystitis, Gonorrhea, Skin and skin structure infections, Tonsillitis, Respiratory tract infections, Acute Maxillary Sinusitis, Acute bacterial exacerbation of chronic bronchitis
Adult Dose
Acute Bronchitis & Acute Exacerbations of Chronic Bronchitis, Acute Maxillary Sinusitis
200 mg PO q12hr for 10 days
Acute Community-Acquired Pneumonia
200 mg PO q12hr for 14 days
Pharyngitis/Tonsillitis
100 mg PO q12hr for 5-10 days
Skin/Skin Structure Infections
400 mg PO q12hr for 7-14 days
Uncomplicated gonorrhoea
200 mg as a single dose
Uncomplicated Urinary Tract Infections
100 mg PO q12hr for 7-14 days
Hepatic impairment
Dosage adjustment not necessary
Child Dose
Child : PO 10 mg/kg/day, max 400 mg/day q12h
6 months - 2 years : 40 mg every 12 hours
3 - 8 years : 80 mg every 12 hours
over 9 years : 100 mg every 12 hours
Renal Dose
Renal impairment: Patients on haemodialysis: Dose should be given after each dialysis session.
CrCl (ml/min) Dosage Recommendation
10-39 Increase dosing intervals to 24 hrly.
<10 Increase dosing intervals to 48 hrly.
Administration
Should be taken with food. Take after meals.
Reconstitution: Reconstitute powd for oral susp at the time of dispensing by adding the amount of water specified on the container to provide a susp containing 50 mg or 100 mg per 5 mL. Add water in 2 equal parts and shake the bottle vigorously after each addition.
Contra Indications
Hypersensitivity.
Precautions
History of allergy to penicillin; severe renal impairment; pregnancy and lactation.
Lactation: Drug excreted in breast milk in low concentrations; not recommended
Pregnancy-Lactation
Interactions
Antacids or H2-blockers may decrease the absorption of cefpodoxime. Probenecid inhibits renal excretion.
Potentially Fatal: Monitor renal function during admin. Additive nephrotoxic effects with furosemide.
Adverse Effects
Side effects of Cefpodoxime :
>10%
Diarrhea in infants and toddlers (15.4%),Diaper rash (12.1%)
1-10%
Diarrhea (7.4%),Nausea (3.8%),Vaginal infection (3.1%),Vomiting (1.1-2.1%),Abdominal pain (1.6%),Rash (1.4%),Headache (1.1%)
Potentially Fatal: Pseudomembranous colitis; nephrotoxicity.
Mechanism of Action
Cefpodoxime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Note
Proxcef D-SY manufactured by Nepal Pharmaceuticals Pvt. Ltd.. Its generic name is Cefpodoxime. Proxcef is availble in Nepal.
Farmaco Nepal drug index information on Proxcef D-SY is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.