Pyricort Ear Drop
Gentamicin + Dexamethasone Ear prep
0.3% w/v+0.1% w/v
FDC Pharmaceutical Pvt. Ltd.
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| Retail Price | 18.08 NPR |
Indications
Pyricort Ear Drop is used for:
Otitis externa
Adult Dose
Otic/Aural
Otitis externa
Adult: Ear drops: Instill 2-3 drops in the affected ear 3-4 times a day and at night.
Child Dose
Otic/Aural
Otitis externa
Child: Instill 2-3 drops in the affected ear 3-4 times a day and at night.
Renal Dose
Administration
Contra Indications
Hypersensitivity to gentamicin and other aminoglycosides. Topical application into the ear for patients w/ known or suspected perforation of ear drum.
Precautions
Monitoring Parameters Monitor renal, hepatic, vestibular and cochlear function.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Gentamicin + Dexamethasone Ear prep :
Ototoxicity, electrolyte disturbances (notably hypomagnesaemia, but also hypocalcaemia and hypokalaemia);
Mechanism of Action
Gentamicin interferes w/ bacterial protein synthesis by binding to 30S and 50S ribosomal subunits resulting in a defective bacterial cell membrane.
Dexamethasone decreases inflammation by suppressing migration of polymorphonuclear leukocytes (PMNs) and reducing capillary permeability; stabilizes cell and lysosomal membranes, increases surfactant synthesis, increases serum vitamin A concentration, and inhibits prostaglandin and proinflammatory cytokines; suppresses lymphocyte proliferation through direct cytolysis, inhibits mitosis, breaks down granulocyte aggregates, and improves pulmonary microcirculation
Note
Pyricort 0.3% w/v+0.1% w/v Ear Drop manufactured by FDC Pharmaceutical Pvt. Ltd.. Its generic name is Gentamicin + Dexamethasone Ear prep. Pyricort is availble in Nepal.
Farmaco Nepal drug index information on Pyricort Ear Drop is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.