Quadriderm AF Cream
Betamethasone + Clotrimazole + Gentamicin Topical
Fulford India Ltd.
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Indications
Quadriderm AF Cream is used for:
Allergic inflammatory skin disease (acute & chronic eczema, contact dermatitis, atopic dermatitis, seborrheic dermatitis, chronic simple lichen, intertrigo, exfoliative dermatitis, papular urticaria, psoriasis, pruritus vulvae, pruritus ani, dermatitis solaris; skin mycosis (athlete's foot, trichophytia); tinea versicolor; insect bite and skin disease by secondary bacterial infection.
Adult Dose
Apply thin film to affected skin areas 2 times daily. Limit treatment to less than 45g per week.
Duration of therapy varies depending upon the extent and location of disease and patient response. However, if clinical improvement is not achieved by 3-4 weeks, diagnosis should be reviewed.
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity to any of the ingredients.
Tuberculosis and most viral lesion of the skin, particularly herpes simplex, vaccinia and varicella.
Precautions
Similar effect to systemic steroid therapy may occur in large amount use or long-term therapy by occlusive dressing technique (ODT). Manifestations hypersensitivity eg, itching, flare, vesicle and urticaria may occur. Discontinue using if these reactions occur. Do not use in overdosage or ODT in prolonged period of therapy.
Do not use in the eyes.
Discontinue use in case of no improvements or condition worsens; as soon as possible improvements happen.
Use in pregnancy & lactation.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Betamethasone + Clotrimazole + Gentamicin Topical :
Continuous application without interruption may result in local atrophy of the skin, striae and superficial vascular dilation. Rarely, patients may experience local mild burning or irritation.
Local adverse effect eg, skin atrophy, facial erythema may occur.
Topical use of gentamicin may cause ototoxicity and/or nephrotoxicity when applied to large burned areas or for extended periods of time, especially in patients with renal insufficiency or when administered concurrently with other drugs that are potentially ototoxic or nephrotoxic.
Mechanism of Action
Betamethasone dipropionate is a synthetic fluorinated corticosteroid. It is active topically and produces a rapid and sustained response in those inflammatory dermatoses that are normally responsive to topical corticosteroid therapy.
Gentamicin sulfate is a bactericidal antibiotic active against a wide variety of pathogenic gram-negative and gram-positive bacteria.
Clotrimazole is a broad-spectrum antifungal. It also exhibit activity against Trichomonas, Staphylococci, Streptococci and Bacteroides.
At a combination of 3 agents with distinct pharmacological effects, Gentriderm offers superior anti-inflammatory, antipruritic, bactericidal and fungicidal action for treatment of inflammatory and allergic dermatological conditions threatened or complicated by bacterial and/or common fungal infections.
Note
Quadriderm AF Cream manufactured by Fulford India Ltd.. Its generic name is Betamethasone + Clotrimazole + Gentamicin Topical. Quadriderm AF is availble in Nepal.
Farmaco Nepal drug index information on Quadriderm AF Cream is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.