R-ZEP Tablet
Pimozide
2mg
Reliance Formulation Pvt Ltd.
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| Retail Price | 5.73 NPR |
Available as:
Indications
R-ZEP Tablet is used for:
Tourette Disorder
Adult Dose
Tourette Disorder
Initial 1-2 mg PO qDay ; increase every other day; not to exceed 10 mg/day
Maintenance: <0.2 mg/kg/day or 10 mg/day, choose lowest dose
Child Dose
Tourette Disorder
< 2 years
Safety & efficacy not established
2-12 years
Initial: 0.05 mg/kg/day PO qHS
Can be increased q3Days to 0.2 mg/kg/day PO qHS
Maintenance dose: 2-4 mg/day; not to exceed 10 mg/day
>12 years
Initial 1-2 mg PO qDay ; increase every other day; not to exceed 10 mg/day
Maintenance: <0.2 mg/kg/day or 10 mg/day, choose lowest dose
Renal Dose
Administration
May be taken with or without food
Contra Indications
Prolonged QT interval, family history of congenital QT prolongation, history of cardiac arrhythmias; severe toxic CNS depression, comatose states; known uncorrected hypokalaemia or hypomagnesaemia. Concomitant use w/ inhibitors of CYP3A4 or CYP2D6 isoenzymes, SSRIs and drugs known to prolong the QT interval.
Precautions
Patient w/ CV diseases, Parkinson's disease, phaeochromocytoma, history of seizures or other conditions that potentially lower the seizure threshold (e.g. alcohol withdrawal, brain damage). CYP2D6 poor metabolisers. Hepatic or renal impairment. Elderly. Pregnancy and lactation. Patient Counselling This drug may impair alertness, esp at the start of treatment, if affected, do not drive or operate machinery. Monitoring Parameters Monitor ECG before and during treatment. Monitor cardiac function and electrolytes periodically.
Pregnancy-Lactation
Interactions
Avoid use w/ drugs that cause electrolyte disturbances (e.g. diuretics). Increased CNS depression produced by other CNS depressants (e.g. hypnotics, sedatives or strong analgesics). Increased risk of extrapyramidal effects w/ anti-emetics (e.g. metoclopramide). Increased risk of CNS toxicity w/ sibutramine. Enhanced hypotensive effect w/ Ca channel blockers. May impair the anti-Parkinson effect of levodopa.
Potentially Fatal: Concurrent use w/ inhibitors of CYP3A4 (e.g. azole antifungals, antiviral protease inhibitors, macrolide antibiotics, nefazodone) or CYP2D6 (e.g. quinidine) may lead to elevated plasma concentrations, increasing the risk of cardiac arrhythmias. Concomitant use w/ SSRIs (e.g. citalopram, escitalopram, paroxetine, sertraline) may cause extrapyramidal effects, oculogyric crises and sedation. Increased risk of arrhythmias due to prolonged QT interval w/ TCAs, terfenadine, astemizole, antimalarials and cisapride.
Adverse Effects
Side effects of Pimozide :
Extrapyramidal effects, sedation, akathisia, akinesia, drowsiness, behaviour changes, somnolence, depression, insomnia, speech disorder, nervousness, headache, abnormal dreams, hyperkinesias; xerostomia, constipation, increased salivation and appetite, diarrhoea, taste disturbances, thirst, dysphagia; impotence, rash; muscle tightness and weakness, rigidity, stooped posture, change in handwriting, myalgia, torticollis, tremor; decreased accommodation, visual disturbances, photophobia.
Potentially Fatal: Neuroleptic malignant syndrome.
Mechanism of Action
Pimozide is a long-acting antipsychotic structurally similar to butyrophenones which block dopaminergic receptors in the CNS, resulting in neuroleptic effects. It also exhibits some Ca-blocking activity.
Note
R-ZEP 2mg Tablet manufactured by Reliance Formulation Pvt Ltd.. Its generic name is Pimozide. R-ZEP is availble in Nepal.
Farmaco Nepal drug index information on R-ZEP Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.