Repace H Tablet
Hydrochlorothiazide + Losartan Potassium
12.5mg + 50mg
Sun Pharmaceutical Industries Ltd.
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| Retail Price | 17.44 NPR |
Available as:
Indications
Repace H Tablet is used for:
Hypertension, Stroke risk reduction of hypertensive or LVH patients
Adult Dose
Hypertension
Initial: 50 mg/12.5 mg PO qDay
If dose titrated upward, do not to exceed final titration of 100 mg/25 mg PO qDay or 50 mg/12.5 mg PO q12hr
Decrease losartan to 25 mg PO qDay initially if volume depleted
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment
CrCl <30 mL/min: Do not use thiazide-containing products; loop diuretic preferred
CrCl >30 mL/min: No dosage adjustment required
Administration
Contra Indications
Pregnancy, lactation; intravascular volume depletion.
Precautions
Existing electrolyte disturbances; hepatic cirrhosis; severe hepatic failure; oedema; elderly (>75 yr); renal impairment; hepatic impairment; diabetes, gout, hyperlipidaemia; hyperuricaemia; ECG: LVH and/or ventricular ectopics extrasystoles); volume depleted patients; patients on diuretics and salt restriction; renal artery stenosis; aortic and mitral stenosis. Monitor potassium concentration. Discontinue before performing tests for parathyroid function.
Lactation: Discontinue drug or do not nurse
Pregnancy-Lactation
Interactions
Reduced excretion of lithium; effect of diuretic, natriuretic & other antihypertensive w/ NSAIDs including selective COX-2 inhibitors. Do not co-administer w/ aliskiren in patients w/ diabetes & renal impairment.
Losartan: Rifampin & fluconazole. Increased serum potassium w/ K-sparing diuretics (eg spironolactone, triamterene, amiloride), K supplements or salt substitutes containing K.
Hydrochlorothiazide: Potentiate orthostatic hypotension w/ alcohol, barbiturates or narcotics. Antidiabetic drugs (oral agents, insulin), other antihypertensive drugs. Impaired absorption w/ cholestyramine & colestipol resins. Intensified electrolyte depletion w/ corticosteroids, ACTH, glycyrrhizin (liquorice). Possible decreased response to pressor amines (eg adrenaline); increased response to nondepolarizing skeletal muscle relaxants (eg tubocurarine). May interfere w/ parathyroid function test.
Adverse Effects
Side effects of Hydrochlorothiazide + Losartan Potassium :
>10%
Losartan
Fatigue (14%),Hypoglycemia (14%),Chest pain (12%),Cough, incidence higher in previous cough related to ACE therapy (3-11%)
1-10%
Losartan
Diarrhea (2-10%),URI (8%),Hypotension (7%),Dizziness (4%),Nausea (2%)
Hydrochlorothiazide
Hypotension,Anorexia,Epigastric distress,Hypokalemia,Phototoxicity,Thrombocytopenia
Potentially Fatal: Hypersensitivity reactions; hemolytic anaemia; toxic epidermal necrolysis.
Mechanism of Action
Hydrochlorothiazide increases renal excretion of sodium and chloride and reduces cardiac load. Losartan is an angiotensin II receptor (type AT1) antagonist antihypertensive which acts by blocking the actions of angiotensin II of renin-angiotensin-aldosterone system. The drug and its active metabolite selectively block the vasoconstrictor and aldosterone secreting effects of angiotensin II. The two drugs exert additive effects in hypertension.
Note
Repace H 12.5mg + 50mg Tablet manufactured by Sun Pharmaceutical Industries Ltd.. Its generic name is Hydrochlorothiazide + Losartan Potassium. Repace H is availble in Nepal.
Farmaco Nepal drug index information on Repace H Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.