Revocon Tablet
Tetrabenazine
25mg
Sun Pharmaceutical Industries Ltd.
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 28.16 NPR |
Indications
Revocon Tablet is used for:
Movement disorders, Moderate to severe tardive dyskinesia
Adult Dose
Oral
Huntington Disease
Indicated for treatment of chorea associated with Huntington’s disease
Adult:
Individualize and slowly titrate dosage over several weeks to identify a dose that reduces chorea and is well tolerated
Total daily dose up to 50 mg/day
12.5 mg PO qDay initially; after 1 week, the dose should be increased to 12.5 mg q12hr
Maintenance: Titrate slowly by weekly intervals of 12.5 mg/day to identify dose that reduces chorea and is tolerated
If daily dose is 37.5 to 50 mg/day, administer in divided doses q8hr
Elderly: Initially 12.5 mg daily, increased gradually.
Total Daily dose >50 mg/day
If >50 mg/day is required, test and genotype to determine if poor or extensive metabolizers of CYP2D6; not to exceed 100 mg/day or 37.5 mg/dose
Moderate to severe tardive dyskinesia
Adult: Initially 12.5 mg daily increased gradually according to response.
Hepatic impairment
Contraindicated; it is not possible to adjust the dose to ensure safe use
Child Dose
Safety and efficacy not established
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity. Lactation. Hepatic impairment. Patients who are actively suicidal, or who have untreated or inadequately treated depression.
Precautions
May exacerbate symptoms of parkinsonism. Caution to be exercised when driving or performing skilled tasks. Pregnancy. Increased risk of depression and suicidal thoughts and behavior (suicidality) in patients with Huntington’s disease. Monitor for emergence or worsening of depression, suicidality, or unusual changes in behavior. Caution in patients with a history of depression or prior suicide attempts or ideation.
Pregnancy-Lactation
Interactions
Tetrabenazine should not be given with or within 14 days of discontinuation of MAOI therapy. Blocks action of reserpine. Decreases effects of levodopa and worsen parkinsonism. Increased risk of extrapyramidal side effects when given with amantadine, metoclopramide, antipsychotics.
Adverse Effects
Side effects of Tetrabenazine :
>10%
Sedation/somnolence (31%),Fatigue (22%),Insomnia (22%),Depression (19%),Akathisia (19%),Extrapyramidal event (15%),Anxiety (15%),Nausea (13%)
1-10%
Irritability (9%),Bruising (6%),Vomiting (6%),Decreased appetite (4%),Dysuria (4%),Obsessive reaction (4%),Imbalance (9%),Parkinsonism/bradykinesia (9%),Dizziness (4%),Dysarthria (4%),Unsteady gait (4%),Headache (4%)
Frequency Not Defined
QTc prolongation,Neuroleptic malignant syndrome,Orthostatic Hypotension,Restlessness and agitation,Dysphagia,Depression and suicidality
Potentially Fatal: Neuroleptic malignant syndrome (NMS).
Mechanism of Action
Tetrabenazine act by depleting nerve endings of dopamine in the brain and is used to control movement disorders.
Note
Revocon 25mg Tablet manufactured by Sun Pharmaceutical Industries Ltd.. Its generic name is Tetrabenazine. Revocon is availble in Nepal.
Farmaco Nepal drug index information on Revocon Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.