RIZORA Tablet
Rizatriptan
5mg
Intas Pharmaceuticals Ltd.
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| Retail Price | 64.80 NPR |
Indications
RIZORA Tablet is used for:
Acute migraine attacks
Adult Dose
Oral
Acute migraine attacks
Adult: Initially, 10 mg. If ineffective, 2nd dose should not be taken for the same attack. If symptoms recur after initial response, a further dose of 10 mg may be given. Doses should be separated by at least 2 hr. Max: 20 mg/24 hr.
If patient is also taking propanolol, initiate with 5 mg. Max: 10 mg/24 hr. Ensure that the 2 drugs are separated by at least 2 hr.
Hepatic Impairment For mild-moderate impairment, initate with 5 mg. Further dose of 5 mg may be taken after an interval of at least 2 hr. Max: 10 mg/24 hr. Avoid in severe impairment.
Child Dose
Migraine Headache
Acute treatment of migraine with or without aura
<6 years: Safety and efficacy not established
6-17 years (<40 kg): 5 mg PO once q24hr
6-17 years: (40 kg or greater): 10 mg PO once q24hr
Dosing considerations
Efficacy and safety of treatment with more than 1 dose within 24 hours in pediatric patients has not been established
6-17 years (<40 kg) taking propranolol: Do not administer rizatriptan
6-17 years (>40 kg) taking propranolol: Limit dose to 5 mg PO once q24hr as necessary; not to exceed 5 mg/24hr
Renal Dose
Renal Impairment
For mild-moderate impairment, initate with 5 mg. Further dose of 5 mg may be taken after an interval of at least 2 hr. Max: 10 mg/24 hr. Avoid in severe impairment.
Administration
May be taken with or without food.
Contra Indications
History of MI, peripheral vascular disease, transient ishaemic attack, ischaemic heart disease or Prinzmetal's angina; uncontrolled hypertension; basilar or hemiplegic migraine; severe hepatic or renal impairment. Adolescent <18 yr.
Precautions
Elderly; mild to moderate hepatic or renal impairment; coronary artery disease; pregnancy, lactation. May cause drowsiness. History of seizures. Ensure an interval of at least 24 hr after stopping an ergotamine compound and starting a serotonin (5-HT1) agonist.
Lactation: Unknown; use with caution in breastfeeding
Pregnancy-Lactation
Interactions
Increased serum concentrations with propranolol. Increased risk of vasospastic reactions when used with ergotamine and methysergide. Concurrent use with SSRIs may increase risk of serotonin syndrome.
Potentially Fatal: Concurrent use with or within 2 wk of stopping MAOI treatment.
Adverse Effects
Side effects of Rizatriptan :
>10%
Drowsiness (13-30%, dose related),Fatigue (13-30%, dose related),Dizziness (11-15%)
1-10%
Dizziness (4-9%),Somnolence (4-8%),Fatigue (4-7%; dose related),Nausea (4-6%),Asthenia (1-5%),Hot flashes (1-5%),Paresthesia (3-4%),Dry mouth (3%),Chest pain (2-3%),Pain/pressure in chest, neck, throat, jaw (<2%),Headache (<2%),Dyspnea (>1%),Hypoesthesia (>1%),Palpations (>1%),Skin flushing (>1%)
<1%
Tachycardia,Angioedema,Wheezing,Hypertensive crisis,Bradycardia,Hallucination,Epidermal necrolysis,Hearing impairment,Arrhythmias,Myocardial infarction and coronary artery vasospasm in patients with CAD risk factors
Potentially Fatal: Toxic epidermal necrolysis.
Mechanism of Action
Rizatriptan is a selective serotonin (5-HT1) agonist in cranial arteries responsible for vasoconstriction and reduction of inflammation associated with antidromic neuronal transmission.
Note
RIZORA 5mg Tablet manufactured by Intas Pharmaceuticals Ltd.. Its generic name is Rizatriptan. RIZORA is availble in Nepal.
Farmaco Nepal drug index information on RIZORA Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.