S amlosafe Tablet
Amlodipine
5mg
Aristo Pharmaceuticals Ltd.
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 6.16 NPR |
Available as:
Indications
S amlosafe Tablet is used for:
Mild to moderate hypertension, Chronic stable and vasospastic angina, Raynaud's disease, Coronary Artery Disease, HTN, Stroke prevention
Adult Dose
Oral
Prinzmetal's angina; Stable angina
Adult: Initially, 5 mg once daily increased to 10 mg once daily if necessary.
Elderly: Initially, 2.5 mg once daily. maintenance: 10 mg/day
Hepatic impairment: Initially, 2.5 mg once daily.
Hypertension
Adult: Initially, 5 mg once daily increased to 10 mg once daily if necessary.
Elderly: Initially, 2.5 mg once daily. may be increased by 2.5 mg/day every 7-14 days; not to exceed 10 mg/day PO; maintenance: 5-10 mg/day PO
Hepatic impairment: Initially, 2.5 mg once daily.
Child Dose
Hypertension
<6 years: Safety and efficacy not established
>6 years: 2.5-5 mg/day PO
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity to Amlodipine or other calcium channel antagonist, Severe hypertension.
Precautions
Impaired liver or renal function, CHF, sick-sinus syndrome, severe ventricular dysfunction, hypertrophic cardiomyopathy, severe aortic stenosis. Caution when used in patients with idiopathic hypertrophic subaortic stenosis. Elderly, children. Pregnancy, lactation. Use in renal failure: Although Amlodipine is excreted primarily via kidney, mild renal impairment does not appear to have an effect on the plasma concentrations. Severe renal impairment may however require a dosage reduction. Amlodipine is not dialyzable. Use in patients with impaired hepatic function: Amlodipine half-life is prolonged in patient with impaired hepatic function. Amlodipine should therefore be administered at lower (5mg) initial dose in these patients. Use in heart failure: An increased number of pulmonary oedema has been reported.
Lactation: Unknown whether drug is excreted in milk; use not recommended
Pregnancy-Lactation
Interactions
Plasma concentrations may be elevated w/ CYP3A4 inhibitors (e.g. azole antifungals, ritonavir). Concomitant therapy w/ simvastatin may increase risk of myopathy including rhabdomyolysis. May increase ciclosporin plasma levels and conivaptan.
Adverse Effects
Side effects of Amlodipine :
>10%
Edema (1.8-10.8%),Pulmonary edema (7-15%)
1-10%
Headache (7.3%),Fatigue (4.5%),Palpitations (0.7-4.5%),Dizziness (1.1-3.4%),Nausea (2.9%),Flushing (0.7-2.6%),Abdominal pain (1.6%),Somnolence (1.4%),Male sexual disorder (1-2%),Drowsiness (1%),Pruritus (1-2%),Skin rash (1-2%),Muscle cramps (1-2%),Muscle weakness (1-2%)
Potentially Fatal: Hypotension, bradycardia, conductive system delay and CCF.
Mechanism of Action
Amlodipine relaxes peripheral and coronary vascular smooth muscle. It produces coronary vasodilation by inhibiting the entry of Ca ions into the slow channels or select voltage-sensitive channels of the vascular smooth muscle and myocardium during depolarisation. It also increases myocardial oxygen delivery in patients w/ vasospastic angina.
Note
S amlosafe 5mg Tablet manufactured by Aristo Pharmaceuticals Ltd.. Its generic name is Amlodipine. S amlosafe is availble in Nepal.
Farmaco Nepal drug index information on S amlosafe Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.