S-Celepra Tablet
Escitalopram
5mg
Micro Labs Ltd.
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| Retail Price | 5.76 NPR |
Available as:
Indications
S-Celepra Tablet is used for:
Major depressive disorder, Depression, Panic disorder, Obsessive compulsive disorder, Anxiety disorder
Adult Dose
Oral
Anxiety; Depression; Obsessive compulsive disorder
Adult: 10 mg once daily, increased after at least a wk if needed. Max: 20 mg once daily.
Panic disorder with or without agoraphobia
Adult: Initially, 5 mg once daily, increased after a wk to 10 mg once daily. Max: 20 mg daily.
Elderly: Half the adult dose.
Hepatic impairment: Mild to moderate: Initially, 5 mg daily, increased to 10 mg daily after 2 wk if needed. Severe: More careful dose titration needed.
Child Dose
Major Depressive Disorder
<12 years: Safety and efficacy not established
>12 years: 10 mg PO qDay; may increase dose after at least 3 weeks; not to exceed 20 mg/day
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Concomitant use with or within 2 wk of MAOI withdrawal.
Precautions
History of mania or seizure disorders; work requiring mental alertness; renal and hepatic impairment; pregnancy, lactation; withdraw gradually.
Lactation
Excreted in breast milk; consider risk/benefit ratio
Pregnancy-Lactation
Interactions
Increased risk of bleeding when used with aspirin, NSAIDs or drugs that affect coagulation. Serum levels may be reduced by CYP2C19 inducers (e.g. carbamazepine, rifampin, phenytoin) or CYP3A4 inducers (e.g. nafcillin, nevirapine). Serum levels may also be increased by CYP2C19 inhibitors (e.g. fluconazole, fluvoxamine, omeprazole) or CYP3A4 inhibitors (e.g. azole antifungals, clarithromycin). May increase serum levels of desipramine or metoprolol. Increased risk of serotonin syndrome when used with linezolid or sibutramine. Escitalopram may enhance the sedative effects of alcohol.
Potentially Fatal: Concomitant administration with MAOIs may lead to serious or fatal reactions; should not be started until at least 2 wk after stopping escitalopram or vice versa. Moclobemide may increase the risk of serotonin syndrome.
Adverse Effects
Side effects of Escitalopram :
>10%
Headache (24%),Nausea (18%),Ejaculation disorder (9-14%),Somnolence (4-13%),Insomnia (7-12%)
1-10%
Xerostomia (4-9%),Constipation (3-6%),Fatigue (2-8%),Libido decrease (3-7%),Anorgasmia (2-6%),Flatulence (2%),Toothache (2%),Weight gain (1%),Menstrual disorder (2%),Neck/shoulder pain (3%),Rhinitis (5%),Flu-like syndrome (5%),Ejaculation disorder (9-14%)
<1%
Arthralgia,Abdominal pain,Abnormal bleeding,Abnormal dreams,Allergy,Blurred vision,Bronchitis,Chest pain,Constipation,Decreased appetite,Decreased concentration,Disrupts platelets/hemostasis,Dizziness,Dyspepsia,Fever,Heartburn,Hot flashes,Impotence,Irritability,Jaw stiffness,Lethargy,Lightheadedness,Menstrual disorder,Hypertension,Palpitations,Migraine,Myalgia,Paresthesia,Rash,Sweating,Tinnitus,Tremor,Urinary frequency,Urinary tract infection,Vertigo,Vomiting,Yawning
Mechanism of Action
Escitalopram selectively inhibits CNS neuronal re-uptake of serotonin (5-HT) and potentiates serotonergic activity. It has minimal effects on norepinephrine and dopamine neuronal re-uptake.
Note
S-Celepra 5mg Tablet manufactured by Micro Labs Ltd.. Its generic name is Escitalopram. S-Celepra is availble in Nepal.
Farmaco Nepal drug index information on S-Celepra Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.