Sertima 100 Tablet
Sertraline Hydrochloride
100mg
Intas Pharmaceuticals Ltd.
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 16.80 NPR |
Available as:
Indications
Sertima 100 Tablet is used for:
Major Depressive illness, Panic disorder, Premenstrual dysphoric disorder, Post-traumatic stress disorder, Obsessive-compulsive disorder, Social anxiety disorder
Adult Dose
Oral
Major Depressive Disorder; Obsessive compulsive disorder
Adult: Initially, 50 mg daily, may increase in increments of 50 mg at wkly intervals. Max: 200 mg daily.
Panic disorder with or without agoraphobia; Posttraumatic stress disorder; Social anxiety disorder
Adult: Initially, 25 mg daily, increased to 50 mg daily after a wk. May increase in increments of 50 mg at wkly intervals. Max: 200 mg daily.
Premenstrual dysphoric disorder
Adult: Initially, 50 mg daily, either throughout the menstrual cycle or during the luteal phase only. May increase in increments of 50 mg per menstrual cycle. Max: 150 mg daily (for continuous dosing) or 100 mg daily (during luteal phase).
Patient who require 100 mg daily during luteal phase-only: Initially, 50 mg daily for the first 3 days of each luteal phase period.
Hepatic impairment: Reduce dose.
Child Dose
Oral
Obsessive compulsive disorder
Child: 6-12 yr Initially, 25 mg once daily;
13-17 yr Initially, 50 mg once daily. May increase at intervals of at least 1 wk.
Max: 200 mg daily.
Renal Dose
Renal impairment: Dose adjustment not necessary
Administration
May be taken with or without food.
Contra Indications
Sertraline is contraindicated in patients with a known hypersensitivity to Sertraline or any of the excipients of drug. Concurrent use or w/in 14 days of discontinuation of MAOIs (e.g. linezolid or IV methylene blue). Concomitant use w/ pimozide.
Precautions
Patient w/ family history of bipolar disorder, mania or hypomania; previous seizure disorder or condition predisposing to seizures (e.g. alcoholism, brain damage); angle-closure glaucoma or history of glaucoma; risk factors for uric acid nephropathy, QTc prolongation. Patient w/ concurrent systemic illness (e.g. conditions that affect metabolism or haemodynamic process). Avoid abrupt withdrawal. Renal and hepatic impairment. Childn. Pregnancy and lactation. Monitoring Parameters Monitor BMI (longitudinal monitoring), height, wt, unusual behavioural changes, signs and symptoms of serotonin syndrome.
Lactation
Distributed into milk; use caution (AAP states effect on nursing infants is unknown but may be of concern)
Pregnancy-Lactation
Interactions
May increase risk of delirium when used with antimuscarinics. Increased risk of extrapyramidal symptoms and neuroleptic malignant syndrome when used with aripiprazole. Serum levels may be reduced by carbamazepine. Concurrent use with dihydroergotamine or linezolid may lead to serotonin syndrome. May increase serum levels of lamotrigine and risk of toxicity. May increase serum levels of olanzapine, pimozide, risperidone, methadone, clozapine and amiodarone. Plasma levels may be increased by cimetidine and ritonavir. May increase the anticoagulant activity of warfarin and acenocoumarol.
Potentially Fatal: Concomitant admin with MAOIs can result in serious serotonin syndrome.
Adverse Effects
Side effects of Sertraline Hydrochloride :
>10%
Diarrhea (13-24%),Nausea (13-30%),Headache (20-25%),Insomnia (12-28%),Ejaculation disorder (7-19%),Dizziness (6-17%),Dry mouth (6-16%),Fatigue (10-16%),Drowsiness (2-15%)
1-10%
Agitation (1-6%),Anorexia (5-10%),Anxiety (4%),Constipation (5-8%),Paresthesia (2%),Impotence (5-10%),Sweating (< 1%),Malaise (7-9%),Vomiting (4%),Pain (3-6%)
Frequency Not Defined
Asthenia,Back pain,Chest pain,Hypoesthesia,Increased appetite,Myalgia,Palpitations,Rhinitis,Tinnitus,Weight gain,Yawning
Mechanism of Action
Sertraline has a potent and selective inhibitory action on CNS neuronal reuptake of 5-HT resulting in increased 5-HT concentrations at the synaptic clefts, leading to sustained activity at the postsynaptic receptor sites and improvement of depression. Reduction of serotonin turnover (in brain) also contributes to its action. Its long half-life allows once daily admin.
Note
Sertima 100 100mg Tablet manufactured by Intas Pharmaceuticals Ltd.. Its generic name is Sertraline Hydrochloride. Sertima 100 is availble in Nepal.
Farmaco Nepal drug index information on Sertima 100 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.