Sinarest Tablet
Caffeine + Chlorpheniramine + Paracetamol + Phenylephrine
(30mg)+(2mg),+(500mg),+(1
Centaur Pharmaceuticals Pvt. Ltd.
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Indications
Sinarest Tablet is used for:
Relief of nasal and sinus congestion.
Relief of allergic symptoms of the nose or throat due to upper respiratory tract allergies.
Relief of sinus pain and headache.
Adjunct with antibacterials in sinusitis, tonsillitis and otitis media.
Adult Dose
Adults:
The usual recommended dose is 1-2 tablets tid or qid.
Child Dose
Children:
The usual recommended dose is 1-2 teaspoonful (5-10 ml) tid or qid.
Renal Dose
Administration
Contra Indications
Hypersensitivity to any of the ingredients of the formulation.
Severe hypertension
Precautions
In case a hypersensitivity reaction occurs which is rare, Tablet/Syrup should be discontinued.
should be used with caution in patients with renal or hepatic dysfunction, diabetes mellitus, hyperthyroidism, cardiovascular problems, epilepsy and closed angle glaucoma.
Pregnancy-Lactation
Interactions
Clinically significant drug interactions may occur on concomitant administration of Tablet/Syrup with monoamine oxidase inhibitors, tricyclic
antidepressants, beta-adrenergic agents, methyldopa, reserpine and veratrum alkaloids.
Adverse Effects
Side effects of Caffeine + Chlorpheniramine + Paracetamol + Phenylephrine :
Generally well tolerated and adverse events are rare.
Hypersensitive individuals may display ephedrine-like reactions such as tachycardia, palpitations, headache, dizziness and nausea. Use of sympathomimetics has been associated with fear, anxiety, restlessness, tremor, weakness, dysuria, insomnia, hallucinations and convulsions. Chlorpheniramine in may cause sedation.
Mechanism of Action
Paracetamol produces analgesia by elevation of the pain threshold and antipyretic effect through action on the hypothalamic heat-regulating center.
Paracetamol
is equal to aspirin in analgesic and antipyretic effectiveness, and it is
unlikely to produce many of the side effects associated with aspirin and aspirin-containing products.
Sympathomimetic decongestants reduce the nasal congestion due to increased nasal blood flow associated with colds and influenza.
Phenylephrine is sympathomimetic vasoconstrictor that has been used as a decongestant. It is a relatively selective alpha-adrenoceptor agonist. The majority of the sympathomimetic action is due to direct stimulation of the adrenoceptors and relatively little is due to an indirect effect via release of noradrenaline. Its pressor action is weaker than that of noradrenaline but of longer duration. At therapeutic doses, it does not cause significant stimulation of the central nervous system.
Chlorpheniramine provides prompt relief of itchy-watery eyes, runny nose, sneezing, itching of the nose or throat due to respiratory allergies.
Caffeine enhances the analgesic activity of Paracetamol and serves to reduce incidence of sedation due to Chlorpheniramine maleate.
The Sodium citrate liquefies mucus and helps expectoration whereas Menthol has a cooling and soothing effect.
Note
Sinarest (30mg)+(2mg),+(500mg),+(1 Tablet manufactured by Centaur Pharmaceuticals Pvt. Ltd.. Its generic name is Caffeine + Chlorpheniramine + Paracetamol + Phenylephrine. Sinarest is availble in Nepal.
Farmaco Nepal drug index information on Sinarest Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.