Sirilept 50 Tablet
Zotepine
50mg
Sun Pharmaceutical Industries Ltd.
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Available as:
Indications
Sirilept 50 Tablet is used for:
Schizophrenia
Adult Dose
Oral
Schizophrenia
Adult: Initially, 25 mg tid, increased at 4-day interval if necessary. Max: 100 mg tid.
Elderly: Initially, 25 mg bid, increased gradually. Max: 75 mg bid.
Hepatic impairment: Initially, 25 mg bid, increased gradually. Max: 75 mg bid.
Child Dose
Renal Dose
Renal impairment: Initially, 25 mg bid, increased gradually. Max: 75 mg bid.
Administration
May be taken with or without food.
Contra Indications
Severe CNS depression. Personal or family history of epilepsy. Acute gout, history of nephrolithiasis. Patients with preexisting QT prolongation. Treatment of behaviour problems in elderly with dementia. Lactation.
Precautions
Hepatic and renal impairment, elderly. Angina pectoris due to coronary artery disease, CV diseases e.g. severe hypertension, history of gout or hyperuricaemia, benign prostatic hyperplasia, urinary retention, angle-closure glaucoma, paralytic ileus, Parkinson's disease, tumours of the adrenal medulla e.g. phaeochromocytoma or neuroblastoma. May impair ability to drive or operate machinery. Avoid abrupt withdrawal.
Monitor ECG in patients at risk of developing arrhythmias before starting treatment. Correct any electrolytes imbalance before treatment commencement and continue ECG and electrolytes monitoring during treatment, especially at each dose increase. Wkly monitoring of liver function for at least the 1st 3 mth of therapy in hepatic impairment. Pregnancy.
Pregnancy-Lactation
Interactions
Increased risk of arrhythmias with drugs that prolong QT interval or cause hypokalaemia. Increased zotepine concentration with fluoxetine, diazepam. Increased CNS depresssion with alcohol, CNS depressants. Additive antimuscarinic effects with antimuscarinics. Additive hypotensive effects with antihypertensives and some anaesthetic drugs.
Potentially Fatal: Increased risk of seizures with high dose of antipsychotic drugs.
Adverse Effects
Side effects of Zotepine :
Headache, asthenia, hypotension, tachycardia, elevated LFT, increased prolactin levels, wt gain, constipation, agitation, anxiety, dizziness, insomnia, somnolence, sweating, blurring of vision. Extrapyramidal symptoms and tardive dyskinesia with prolonged treatment. GI disturbances, blood dyscrasias, photosensitisation.
Potentially Fatal: Neuroleptic malignant syndrome.
Mechanism of Action
Zotepine is an atypical antipsychotic that is an antagonist at central dopamine (D1 and D2) receptors. It also binds to serotonin, adrenergic (α1), and histamine (H1) receptors, and inhibits noradrenaline reuptake.
Note
Sirilept 50 50mg Tablet manufactured by Sun Pharmaceutical Industries Ltd.. Its generic name is Zotepine. Sirilept 50 is availble in Nepal.
Farmaco Nepal drug index information on Sirilept 50 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.