Skelebenz Tablet
Cyclobenzaprine Hydrochloride
15mg
Sun Pharmaceutical Industries Ltd.
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Available as:
Indications
Skelebenz Tablet is used for:
Fibromyalgia, Muscle spasm
Adult Dose
Oral
Painful muscle spasm associated with musculoskeletal conditions
Adult: 5 mg tid, may increase to 10 mg tid if needed. Treatment should not last more than 2-3 wk. Max: 60 mg.
Elderly: Initiate with 5 mg with less frequent dosing.
Max Dosage: 60 mg.
Hepatic impairment: MIld: Start with 5 mg dose with less frequent dosing. Moderate to severe: Not recommended.
Child Dose
Muscle Spasm
Oral
<15 years: Safety and efficacy not established
>15 years: 5 mg PO q8hr; may increase dose to 10 mg PO q8hr PRN
Renal Dose
Administration
Contra Indications
Recent MI, arrhythmias, severe liver disease.
Precautions
Cardiac disease, history of epilepsy, hepatic impairment, hyperthyroidism, pheochromocytoma, history of mania, psychoses, close-angle glaucoma, history of urinary retention, concurrent electroconvulsive therapy, diabetes. Pregnancy and lactation; elderly, child. Unsafe for use in patients with porphyria. Avoid abrupt withdrawal. May cause drowsiness; do not drive or operate machinery. Treatment for more than 2-3 wk is not recommended.
Lactation: Excretion in milk unknown; use with caution
Pregnancy-Lactation
Interactions
Plasma concentration may be increased with the use of cimetidine, diltiazem, disulfiram, methylphenidate, ritonavir, and verapamil. Side-effects are increased by adrenaline, amiodarone, general anesthetics, SSRIs, antihistamines, antimuscarinics, antipsychotics, anxiolytics and hypnotics, clozapine, disopyramide, diuretics, flecainide, MAOIs, moclobemide, moxifloxacin, nefopam, nicorandil, noradrenaline, phenothiazine, pimozide, procainamide, propafenone, quinidine, selegiline, sibutramine, sotalol, terfenadine, thioridazine, and tramadol.
Effects of adrenergic neurone blockers, clonidine, barbiturates, nitrates, and primidone are reduced while effects of baclofen, opioid analgesics, and thyroid hormones are enhanced with concomitant use of cyclobenzaprine. Carbamazepine and rifampicin may increase metabolism of cyclobenzaprine. Effects may be antagonized by oestrogens. Avoid use with brimonidine, entacapone, artemether with lumefantrine, or sibutramine. CNS effects may be enhanced by other CNS depressants.
Adverse Effects
Side effects of Cyclobenzaprine Hydrochloride :
>10%
Drowsiness (up to 39% immediate-release),Dry mouth (21-32%),Dizziness (3-11%)
1-10%
Pharyngitis (1-3%),Headache (1-5%),Fatigue (6%),Palpitations (6%),Bad taste in mouth (1-6%),Indigestion (4%),Blurred vision (3%),Constipation (1-3%),Asthenia (1-3%),Confusion (1-3%),Nausea (1-3%),Nervousness (1-3%)
<1%
Arrhythmia,Hypotension,Palpitation,Syncope,Tachycardia,Vasodilation,Cardiac dysrhythmia (rare),Cholestasis (rare),Hepatitis,Jaundice,Anaphylaxis (rare),Immune hypersensitivity reaction
Mechanism of Action
Cyclobenzaprine, a centrally-acting skeletal muscle relaxant, is structurally related to tricyclic antidepressants, thus they share similar properties. It acts on the brain stem, decreasing tonic-somatic motor activities influencing both the ? and ? motor systems. It is used as an adjunct in the symptomatic treatment of painful muscle spasms associated with musculoskeletal conditions.
Note
Skelebenz 15mg Tablet manufactured by Sun Pharmaceutical Industries Ltd.. Its generic name is Cyclobenzaprine Hydrochloride. Skelebenz is availble in Nepal.
Farmaco Nepal drug index information on Skelebenz Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.