Sonate Tablet
Sodium Bicarbonate
300mg
Magnus Pharma Pvt. Ltd.
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| Retail Price | 300.00 NPR |
Available as:
Indications
Sonate Tablet is used for:
Dyspepsia, Urine alkalinisation, Severe metabolic acidosis, Hyperkalemia
Adult Dose
Oral
Urine alkalinisation
Adult: To prevent development of uric-acid renal calculi in the initial stages of uricosuric therapy for hyperuricaemia in chronic gout: Up to 10 g daily in divided doses, to be taken with a liberal amount of fluid.
Chronic metabolic acidosis
Adult: Doses providing 57 mmol (4.8 g sodium bicarbonate) or more daily as required.
Dyspepsia
Adult: 1-5 g in water, may be taken as required.
Intravenous
Severe metabolic acidosis
Adult: By slow inj of a hypertonic solution of up to 8.4% (1000 mmol/L), or by continuous infusion of a weaker solution, usually 1.26% (150 mmol/L). For correction of acidosis during advanced cardiac life support procedures, 50 ml of an 8.4% solution may be given.
Elderly: Dosage adjustments may be required.
Hepatic impairment: Dosage adjustments may be required.
Child Dose
Renal Dose
Renal impairment: Dosage adjustments may be required.
Administration
Should be taken on an empty stomach (i.e. At least one hour before food or two hours after food).
Contra Indications
Metabolic or respiratory alkalosis; hypernatraemia, severe pulmonary oedema; hypocalcaemia, hypochlorhydria.
Precautions
Epilepsy, CHF, renal impairment, liver cirrhosis, hypertension, oedema, eclampsia, aldosteronism. Monitor serum electrolyte concentrations and acid-base status regularly during treatment of acidosis. Pregnancy; lactation.
Pregnancy-Lactation
Interactions
Increases toxicity of amphetamines, ephedrine, pseudoephedrine, flecainide, quinidine and quinine. Decreases effects of lithium, chlorpropamide and salicylates due to increased clearance. May affect the absorption of certain drugs due to raised intra-gastric pH.
Adverse Effects
Side effects of Sodium Bicarbonate :
Aggravated CHF, Cerebral hemorrhage, Edema, Hypernatremia, Hypocalcemia, Hypokalemia, Tetany. Tissue necrosis at inj site.
Mechanism of Action
Sodium bicarbonate raises blood and urinary pH by dissociation to provide bicarbonate ions, which neutralises the hydrogen ion concentration. It also neutralises gastric acid via production of carbon dioxide.
Note
Sonate 300mg Tablet manufactured by Magnus Pharma Pvt. Ltd.. Its generic name is Sodium Bicarbonate. Sonate is availble in Nepal.
Farmaco Nepal drug index information on Sonate Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.