Stag 40 Capsule
Stavudine
40mg
Hetero Drugs Ltd.
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Available as:
Indications
Stag 40 Capsule is used for:
HIV infection
Adult Dose
Oral
HIV infection
Adult:
>60 kg: 40 mg PO BID
<60 kg: 30 mg PO BID
Child Dose
HIV Infection
Birth-13 days: 0.5 mg/kg PO q12hr
<30 kg, >14 days: 1 mg/kg PO q12hr
30-<60 kg: As adults; 30 mg PO BID
>60 kg: As adults; 40 mg PO BID
Renal Dose
Renal Impairment
>60 kg
CrCl >50 mL/min: 40 mg PO q12hr
CrCl 26-50 mL/min: 20 mg PO q12hr
CrCl 10-25 mL/min: 20 mg PO qD
<60 kg
CrCl >50 mL/min: 30 mg PO q12hr
CrCl 26-50 mL/min: 15 mg PO q12hr
CrCl 10-25 mL/min: 15 mg PO qD
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity. Lactation.
Precautions
Hepatomegaly or other risk factors for liver disease. History of peripheral neuropathy and renal impairment. Pregnancy. Discontinue treatment if peripheral neuropathy develops; may resume treatment at half the previous dose if symptoms resolve upon drug withdrawal. Monitor for signs of pancreatitis. Discontinue treatment if there is a rapid increase in aminotransferase concentrations, progressive hepatomegaly or steatosis, or metabolic or lactic acidosis. Increased risk of severe and fatal hepatic adverse events in patients with chronic hepatitis B or C treated with combination antiretroviral therapy.
Lactation: HIV+ women are advised not to breastfeed
Pregnancy-Lactation
Interactions
Antiviral effect inhibited by zidovudine, doxorubicin and ribavirin. Avoid concurrent admin with drugs that cause pancreatitis (e.g. IV pentamidine) or peripheral neuropathy (e.g. metronidazole, isoniazid and vincristine). Increased risk of adverse effects such as hepatoxicity, peripheral neuropathy and pancreatitis if used with hydroxycarbamide and didanosine.
Adverse Effects
Side effects of Stavudine :
>10%
Headache,Chills/fever,Malaise,Insomnia,Anxiety,Depression,Pain,Rash,Nausea,Vomiting,Diarrhea,Pancreatitis,Abdominal pain,Peripheral neuropathy
1-10%
Neutropenia,Thrombocytopenia,Incr hepatic transaminases,Incr bilirubin,Myalgia,Back pain,Weakness
Mechanism of Action
Stavudine is converted intracellularly to the active metabolite stavudine 5'-triphosphate which is then incorporated into the viral DNA by reverse transcriptase resulting in premature ending of the DNA chain elongation.
Note
Stag 40 40mg Capsule manufactured by Hetero Drugs Ltd.. Its generic name is Stavudine. Stag 40 is availble in Nepal.
Farmaco Nepal drug index information on Stag 40 Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.