Strep 750 Injection

Streptomycin
750mg
Shiv Pharmaceutical Laboratories
Pack size 1
Dispensing mode
Source
Agent
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Indications

Strep 750 Injection is used for: Tuberculosis, Bacterial endocarditis, Plague, Tularaemia, Brucellosis

Adult Dose

Intramuscular Tuberculosis Adult: 15 mg/kg as a single dose daily. Max: 1 g daily. As part of intermittent regimen: 25-30 mg/kg 2-3 times wkly. Max: 1.5 g/dose. Bacterial endocarditis Adult: Streptococcal endocarditis: 1 g bid for 1 wk, then 500 mg bid for the 2nd wk. Enterococcal endocarditis: 1 g bid for 2 wk then 500 mg bid for 4 wk. Doses are given in combination w/ penicillin. Bacteraemia; Meningitis; Pneumonia ; Brucellosis; Urinary tract infections Adult: For concomitant use w/ other agents and as 2nd line agent: 1-2 g daily in divided doses 6-12 hrly. Max: 2 daily. Plague Adult: 2 g daily in 2 divided doses for a minimum of 10 days. Tularaemia Adult: 1-2 g daily in divided doses for 7-14 days until the patient is afebrile for 5-7 days.

Child Dose

Child: Moderate to Severe Infections: IM usually 20–30 mg/kg/day, max 1 g/day q12h Intramuscular Tuberculosis Child: 20-40 mg/kg as a single dose daily. Max: 1 g daily. As part of intermittent regimen: 25-30 mg/kg 2-3 times wkly. Max: 1.5 g/dose. Bacterial endocarditis Child: Enterococcal endocarditis: 20-30 mg/kg daily in 2 divided doses, in combination w/ penicillin. Bacteraemia; Meningitis; Pneumonia ; Brucellosis; Urinary tract infections Child: 20-40 mg/kg daily in divided doses 6-12 hrly. Plague Child: 30 mg/kg daily in 2-3 divided doses. Max: 2 g daily. Tularaemia Child: 15 mg/kg bid for at least 10-14 days. Max: 2 g daily.

Renal Dose

Renal Impairment Load: 1 g IM, THEN CrCl: 50-80 mL/min: 7.5 mg/kg IM q24hr CrCl: 10-50 mL/min: 7.5 mg/kg IM q24-72hr CrCl <10 mL/min: 7.5 mg/kg IM q72-96hr Hemodialysis: 50-75% of initial loading dose at end of dialysis period

Administration

Reconstitution: Add 4.2 mL, 3.2 mL, or 1.8 mL of sterile water for inj to prepare a soln containing approx 200 mg, 250 mg, or 400 mg, respectively, of streptomycin per mL.

Contra Indications

Hypersensitivity to streptomycin and other aminoglycosides.

Precautions

Patient w/ neuromuscular disorders (e.g. myasthenia gravis), pre-existing vertigo, or hearing loss. Renal impairment. Elderly, childn. Pregnancy and lactation. Monitoring Parameters Monitor renal and auditory function.

Pregnancy-Lactation

Interactions

H1-receptor blockers may mask early signs of ototoxicity. May reduce excretion of zalcitabine. May inhibit ?-galactosidase activity. Potentially Fatal: Potentiates nephrotoxicity produced by other aminoglycosides, vancomycin and some cephalosporins. Potentiates ototoxicity produced by other aminoglycosides, ethacrynic acid, mannitol, furosemide and other diuretics.

Adverse Effects

Side effects of Streptomycin : Neurotoxic reactions (e.g. vestibular and cochlear function disturbance, optic nerve dysfunction, peripheral neuritis, arachnoiditis, encephalopathy); paraesthesia of face, rash, fever, angioneurotic oedema, eosinophilia; exfoliative dermatitis, azotemia, leucopenia, thrombocytopenia, pancytopenia, haemolytic anaemia, muscular weakness, amblyopia. Potentially Fatal: Resp paralysis from neuromuscular blockade, Clostridium difficile-associated diarrhoea, anaphylaxis; rarely, nephrotoxicity.

Mechanism of Action

Streptomycin is bactericidal which inhibits bacterial protein synthesis. Susceptible organisms include Mycobacterium tuberculosis, Pasteurella pestis, P.tularensis, Brucella, H.influenzae, H.ducreyi, Klebsiella pneumonia, Escherichia coli, Proteus spp., Aerobacter aerogenes, Streptococcus faecalis, and Streptococcus viridans.

Note

Strep 750 750mg Injection manufactured by Shiv Pharmaceutical Laboratories. Its generic name is Streptomycin. Strep 750 is availble in Nepal. Farmaco Nepal drug index information on Strep 750 Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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