Sulbacin Injection
Ampicillin + Sulbactam
Unichem Laboratories Ltd.
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 201.45 NPR |
Indications
Sulbacin Injection is used for:
Gynaecological infections; Intra-abdominal infections; Skin and skin structure infections, Orbital Cellulitis, Pelvic Inflammatory Disease, Pneumonia, Urinary Tract Infections
Adult Dose
Parenteral
Gynaecological infections; Intra-abdominal infections; Skin and skin structure infections
Adult: Each vial contains 1.5 g (ampicillin 1 g and sulbactam 0.5 g) or 3 g (ampicillin 2 g and sulbactam 1 g): 1.5-3 g 6 hrly by deep IM or slow IV inj over 10-15 min or infusion over 15-30 min.
Max: 12 g (8 g ampicillin and 4 g sulbactam) daily.
Orbital Cellulitis
3 g (2 g ampicillin + 1 g sulbactam) IV q6hr
Pelvic Inflammatory Disease
3 g (2 g ampicillin + 1 g sulbactam) IV q6hr
Pneumonia
Aspiration or community acquired: 1.5 g (1 g ampicillin + 0.5 g sulbactam) to 3 g (2 g ampicillin + 1 g sulbactam) IV q6hr for 5 or more days
Hospital acquired: 3 g IV q6hr for 5 or more days
Urinary Tract Infections
Pyelonephritis: 3 g (2 g ampicillin + 1 g sulbactam) IV q6hr for 14 days
Child Dose
Parenteral
Gynaecological infections; Intra-abdominal infections; Skin and skin structure infections
Child: >1 yr 300 mg/kg daily (ampicillin 200 mg and sulbactam 100 mg) in divided doses 6 hrly by IV infusion.
Renal Dose
Renal impairment: Haemodialysis patient: 1.5-3 g once 24 hrly immediately after dialysis.
CrCl (ml/min) Dosage Recommendation
5-14 1.5-3 g 24 hrly.
15-29 1.5-3 g 12 hrly.
Administration
IV/IM Preparation
Reconstitute with SWI or 0.5% or 2% lidocaine injection (IM) to obtain a 250 mg ampicillin-125 mg sulbactam/mL solution
IM: Use within 1 hr after preparation
IV: Further dilute to 3-45 mg/mL with appropriate diluent
IV/IM Administration
Administer around-the-clock to promote less variation in peak and trough serum levels
Slow IV injection over at least 10-15 min or infusion over 15-30 min
IM: Deep into large muscle mass
Contra Indications
Hypersensitivity to ampicillin, sulbactam or other β-lactam antibacterials (e.g. penicillins, cephalosporins). History of cholestatic jaundice/hepatic dysfunction associated w/ ampicillin and sulbactam.
Precautions
Patient w/ infectious mononucleosis. Hepatic and renal impairment. Pregnancy and lactation. Monitoring Parameters Monitor haematologic, renal and hepatic function w/ prolonged therapy. Monitor for signs of anaphylaxis during 1st dose. Regular monitoring of hepatic function in patients w/ pre-existing hepatic impairment at regular intervals.
Lactation: Excreted in breast milk; use caution
Pregnancy-Lactation
Interactions
Increased and prolonged serum levels w/ probenecid. Increased incidence of rashes w/ allopurinol. May reduce effectiveness of oestrogen-containing OC. May increase risk of methotrexate toxicity. Bacteriostatic drugs (e.g. chloramphenicol) may interfere w/ the bactericidal effect of ampicillin. Additive effect w/ anticoagulants.
Adverse Effects
Side effects of Ampicillin + Sulbactam :
>10%
IM injection site pain (16%)
1-10%
Diarrhea (3%),IV injection site pain (3%),Thrombophlebitis (3%),Rash ( < 2%)
<1%
Abdominal distention,Black, "hairy" tongue,Candidiasis,Chest pain,Chills,Dysuria,Edema,Epistaxis,Erythema,Fatigue,Flatulence,Glossitis,Headache,Itching,Malaise,Mucosal bleeding,Nausea
Pseudomembranous colitis,Seizure,Tightness in throat,Thrombocytopenia,Urine retention,Vomiting
Mechanism of Action
Ampicillin binds to 1 or more of the penicillin-binding proteins (PBPs), thus inhibiting the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. Sulbactam inhibits the activity of beta-lactamases and extends the spectrum of ampicillin to include beta-lactamase producing organisms.
Note
Sulbacin Injection manufactured by Unichem Laboratories Ltd.. Its generic name is Ampicillin + Sulbactam. Sulbacin is availble in Nepal.
Farmaco Nepal drug index information on Sulbacin Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.