Suminat Tablet

Sumatriptan
25mg
Sun Pharmaceutical Industries Ltd.
Pack size 1
Dispensing mode
Source
Agent
Retail Price 54.13 NPR

Indications

Suminat Tablet is used for: Migraine, Cluster headache

Adult Dose

Oral Migraine Adult: >18 yr: 50-100 mg repeated at 2-hr intervals if migraine recurs. Max: 200 mg/24 hr. Mild to moderate hepatic impairment: Max single dose: 50 mg. Severe hepatic impairment: Contraindicated

Child Dose

<18 years: Safety and efficacy not established

Renal Dose

Administration

May be taken with or without food.

Contra Indications

Not to be used prophylactically and in patients with basilar or hemiplegic or ophthalmoplegic migraine. History of MI or stroke, severe hepatic impairment, ischaemic heart disease, uncontrolled hypertension, peripheral vascular disease, hypersensitivity to sulfonamides.

Precautions

Conditions predisposing to seizures, presence of coronary risk factors, cardiac arrhythmias, renal or hepatic impairment, elderly, pregnancy, lactation. Lactation: Excreted in breast milk at very low levels; minimize infant to potential exposure by avoiding breastfeeding for 8-12 hours after administration

Pregnancy-Lactation

Interactions

Concurrent use increased risk of vasospastic reaction with ergotamine and related compounds. Potentially Fatal: Increased risk of serotonin syndrome with concurrent use of SSRI, MAOIs or within 14 days of stopping MAOIs. Admin of ergotamine or related compounds within the previous 24 hr.

Adverse Effects

Side effects of Sumatriptan : >10% Injection site reaction (<86%),Paresthesia (5-14%),Dizziness (12%),Warm/hot sensation (11%) 1-10% Chest discomfort/pressure/tightness (2-5%),Jaw or neck tightness (1-5%),Diaphoresis (2%),Burning sensation (7%),Cold sensation (1%),Dysphagia,Sore throat (3%),Malaise (1%),Abdominal distress (1%) Frequency Not Defined Agitation,Cardiac arrhythmia: V-fib/V-tach (rare),Dysuria,Eye irritation,Flushing,MI and coronary artery vasospasm in patients with CAD risk factors (extremely rare),Nasal discomfort,Palpitations,Tingling,Weakness Potentially Fatal: Cardiac arrhythmias, MI.

Mechanism of Action

Sumatriptan is a selective serotonin agonist that acts at 5-HT1 receptors. It causes vasoconstriction of cranial arteries and/or inhibition of neurogenic inflammatory processes in the CNS. A small but significant delay in gastric emptying also occurs.

Note

Suminat 25mg Tablet manufactured by Sun Pharmaceutical Industries Ltd.. Its generic name is Sumatriptan. Suminat is availble in Nepal. Farmaco Nepal drug index information on Suminat Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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