Supirocine B Plus Ointment

Mupirocin + Beclomethasone Dipropionate Topical
2%W/W + 0.025%W/V
Glenmark Pharmaceuticals Ltd.
Pack size 5gm
Dispensing mode
Source
Agent
Retail Price 267.21 NPR

Indications

Supirocine B Plus Ointment is used for: Used in the treatment of Secondary bacterial skin infections and impetigo.

Adult Dose

Topical/Cutaneous Secondary skin infections Adult: Apply to affected area tid for up to 10 days; re-evaluate after 3-5 days if no clinical response. Impetigo Adult: Apply to affected area tid for 5-10 days; re-evaluate after 3-5 days if no clinical response.

Child Dose

Topical/Cutaneous Secondary skin infections Child: >3 mth Apply to affected area tid for up to 10 days; re-evaluate after 3-5 days if no clinical response. Impetigo Child: >2 mth Apply to affected area tid for 5-10 days; re-evaluate after 3-5 days if no clinical response.

Renal Dose

Administration

Clean and dry the affected area and gently massage the ointment. Wash your hands after applying, unless hands are the affected area.

Contra Indications

This drug is contraindicated in individuals with a history of sensitivity reactions to Mupirocin or any of the components of the preparation.

Precautions

Patient w/ extensive burns and wounds. Renal impairment. Childn. Pregnancy and lactation. Prolonged use may result in overgrowth of nonsusceptible organisms, including fungi Lactation: Not known if distributed into milk; recommended that nursing be temporarily discontinued during therapy

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Mupirocin + Beclomethasone Dipropionate Topical : Burning, stinging, pruritus, pain, rash, erythema, dry skin, tenderness, cellulitis, pain or bleeding secondary to eczema, secondary wound infection, urticaria, swelling, increased exudates, contact dermatitis, furunculosis, exfoliative dermatitis. Rarely, systemic reactions (e.g. nausea, headache, dizziness, abdominal pain, ulcerative stomatitis, systemic allergic reactions).

Mechanism of Action

Mupirocin inhibits protein synthesis of the bacteria by binding to isoleucyl transfer RNA-synthetase. It is active against gram-positive and some gram-negative bacteria. Beclometasone (as diproprionate) is a prodrug w/ potent glucocorticoid and weak mineralocorticoid activity. It controls the rate of protein synthesis, depresses the migration of polymorphonuclear leukocytes, reduces fibroblast activity, and reverses capillary permeability and lysosomal stabilisation at the cellular level to prevent or control inflammation.

Note

Supirocine B Plus 2%W/W + 0.025%W/V Ointment manufactured by Glenmark Pharmaceuticals Ltd.. Its generic name is Mupirocin + Beclomethasone Dipropionate Topical. Supirocine B Plus is availble in Nepal. Farmaco Nepal drug index information on Supirocine B Plus Ointment is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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