Supirocine B Plus Ointment
Mupirocin + Beclomethasone Dipropionate Topical
2%W/W + 0.025%W/V
Glenmark Pharmaceuticals Ltd.
| Pack size | 5gm |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 267.21 NPR |
Indications
Supirocine B Plus Ointment is used for:
Used in the treatment of Secondary bacterial skin infections and impetigo.
Adult Dose
Topical/Cutaneous
Secondary skin infections
Adult: Apply to affected area tid for up to 10 days; re-evaluate after 3-5 days if no clinical response.
Impetigo
Adult: Apply to affected area tid for 5-10 days; re-evaluate after 3-5 days if no clinical response.
Child Dose
Topical/Cutaneous
Secondary skin infections
Child: >3 mth Apply to affected area tid for up to 10 days; re-evaluate after 3-5 days if no clinical response.
Impetigo
Child: >2 mth Apply to affected area tid for 5-10 days; re-evaluate after 3-5 days if no clinical response.
Renal Dose
Administration
Clean and dry the affected area and gently massage the ointment. Wash your hands after applying, unless hands are the affected area.
Contra Indications
This drug is contraindicated in individuals with a history of sensitivity reactions to Mupirocin or any of the components of the preparation.
Precautions
Patient w/ extensive burns and wounds. Renal impairment. Childn. Pregnancy and lactation. Prolonged use may result in overgrowth of nonsusceptible organisms, including fungi
Lactation: Not known if distributed into milk; recommended that nursing be temporarily discontinued during therapy
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Mupirocin + Beclomethasone Dipropionate Topical :
Burning, stinging, pruritus, pain, rash, erythema, dry skin, tenderness, cellulitis, pain or bleeding secondary to eczema, secondary wound infection, urticaria, swelling, increased exudates, contact dermatitis, furunculosis, exfoliative dermatitis.
Rarely, systemic reactions (e.g. nausea, headache, dizziness, abdominal pain, ulcerative stomatitis, systemic allergic reactions).
Mechanism of Action
Mupirocin inhibits protein synthesis of the bacteria by binding to isoleucyl transfer RNA-synthetase. It is active against gram-positive and some gram-negative bacteria.
Beclometasone (as diproprionate) is a prodrug w/ potent glucocorticoid and weak mineralocorticoid activity. It controls the rate of protein synthesis, depresses the migration of polymorphonuclear leukocytes, reduces fibroblast activity, and reverses capillary permeability and lysosomal stabilisation at the cellular level to prevent or control inflammation.
Note
Supirocine B Plus 2%W/W + 0.025%W/V Ointment manufactured by Glenmark Pharmaceuticals Ltd.. Its generic name is Mupirocin + Beclomethasone Dipropionate Topical. Supirocine B Plus is availble in Nepal.
Farmaco Nepal drug index information on Supirocine B Plus Ointment is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.