Syndopa CR Tablet
Carbidopa + Levodopa
100mg + 25mg
Sun Pharmaceutical Industries Ltd.
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| Retail Price | 6.91 NPR |
Available as:
Indications
Syndopa CR Tablet is used for:
Parkinson's disease.
Adult Dose
Parkinson Disease & Parkinson like Disorders
Adult: PO: Immediate release: 25 mg/100 mg q8hr or 10 mg/100 mg PO q6-8hr initially; levodopa may be increased by 100 mg/day every 1-2 days
Carbidopa should be 70-100 mg/day but not to exceed 200 mg/day; levodopa not to exceed 800 mg/day
CR tablet: 50 mg/200 mg PO q12hr initially; may be increased up to 1600 mg/day of levodopa; doses must be given at least 6 hours apart
Hepatic impairment: Safety and efficacy not established; use with caution
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment: Safety and efficacy not established; use with caution
Administration
Contra Indications
Lactation, narrow angle glaucoma, melanoma, psychosis, severely decompensated endocrine.
Precautions
Heart disease, liver disease, dementia, psychosis, pregnancy, elderly, heart disease. Regular monitoring of renal and hepatic function is reccomended.
Lactation: Drug inhibits lactation; use with caution
Pregnancy-Lactation
Interactions
Pyridoxine reverses effects of levodopa. Type-B MAOIs have synergistic effect. Effect reduced by phenothiazines, haloperidol, reserpine, pyridoxine, diazepam, oxazepam, chlordiazepoxide, phenobarbitone. Effects of levodopa enhanced by carbidopa, amantadine, anticholinergics, amphetamine. Effects of sympathomimetic agents enhanced.
Potentially Fatal: Enhances hypotensive effects of bethanidine, bretylium, guanethidine. Hypertensive crises with furazolidone or MAO inhibitors.
Adverse Effects
Side effects of Carbidopa + Levodopa :
Edema,Agitation, anxiety, ataxia, bruxism, confusion, daytime somnolence decreased attention span, dyskinesia, dystonia, euphoria, insomnia, fainting, fatigue, increased trembling of hands, insouciance, malaise, memory loss, nightmares, nervousness, restlessness, trismus, vivid dreams,Alopecia, hot flushes, increased &/or dark perspiration, skin eruptions,Abdominal pain & discomfort, burning feeling in tongue, constipation, diarrhea, dysgeusia, dry mouth, dysphagia, hiccups, meteorism, sialorrhea, nausea, weight loss,Muscular spasms, muscular cramp,Hematuria, dark urine, incontinence, priapism, urine retention,Blurred vision, diplopia, dilated pupil, oculogyric problems.
Potentially Fatal: Severe postural hypotension in elderly.
Mechanism of Action
Levodopa is the metabolic precurosor of dopamine, it crosses the blood-brain barrier and is converted to dopamine in the brain. Carbidopa increases the amount of levodopa that is transported into the CNS by inhibiting the decarboxylation of peripheral levodopa.
Note
Syndopa CR 100mg + 25mg Tablet manufactured by Sun Pharmaceutical Industries Ltd.. Its generic name is Carbidopa + Levodopa. Syndopa CR is availble in Nepal.
Farmaco Nepal drug index information on Syndopa CR Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.