Synogel Syrup
Aluminium Hydroxide + Magnesium Hydroxide + Simethicon
1's
Siddhartha Pharmaceuticals Pvt. Ltd.
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| Retail Price | 100.00 NPR |
Indications
Synogel Syrup is used for:
Dyspepsia, Flatulence
Adult Dose
Adult: Dyspepsia, Abdominal Bloating
10-20 mL PO q4-6hr taken 1 hour before or 3 hours after meals, OR
Chew 2-4 tablets q4-6hr; not to exceed 12 tablets/24 hr
PO Antacid Up to 1 g/day.
Hyperphosphataemia in chronic renal failure Up to 10 g/day in divided doses w/ meals.
Child Dose
Renal Dose
Administration
Should be taken on an empty stomach.
Contra Indications
Hypersensitivity to aluminium salts.
Precautions
Chronic renal impairment; CHF; oedema; cirrhosis and low Na diets; patients with recent GI haemorrhage. Administer 2-3 hrs before/after another medication to minimise drug interactions. Pregnancy and lactation.
Lactation: excretion in milk unknown
Pregnancy-Lactation
Interactions
Aluminium Hydroxide: Enhanced absorption with citrates or ascorbic acid. Decreases absorption of allopurinol, tetracyclines, quinolones, cephalosporins, biphosphonate derivatives, corticosteroids, cyclosporin, delavirdine, Fe salts, imidazole antifungals, isoniazid, mycophenolate, penicillamine, phosphate supplements, phenytoin, phenothiazines, trientine.
Magnesium Hydroxide: Decreases absorption of tetracyclines and biphosphonates. Separate administration of these and other drugs by around 2 hr.
Simethicon: None well documented.
Adverse Effects
Side effects of Aluminium Hydroxide + Magnesium Hydroxide + Simethicon :
Aluminum hydroxide
Chalky taste,Constipation,Fecal impaction,Stomach cramps,Nausea,Vomiting,Rebound hyperacidity,Aluminum intoxication,Hypophosphatemia,Milk-alkali syndrome,Osteomalacia
Magnesium hydroxide
Diarrhea,Hypermagnesemia
Simethicone
Loose stools
Mechanism of Action
Aluminum hydroxide: Neutralizes stomach hydrocloride to form AlCl3 salt plus water; increases gastric pH.
Magnesium hydroxide: Promotes bowel evacuation by causing osmotic retention of fluid, which causes the colon to distend with increased peristaltic activity; forms magnesium chloride when reacts with hydrochloric acid.
Simethicone: Disperses and prevents gas pockets in the GI system by decreasing surface tension of gas bubles.
Note
Synogel 1's Syrup manufactured by Siddhartha Pharmaceuticals Pvt. Ltd.. Its generic name is Aluminium Hydroxide + Magnesium Hydroxide + Simethicon. Synogel is availble in Nepal.
Farmaco Nepal drug index information on Synogel Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.