TABROL-D.S. Tablet
Sulphadiazine + Trimethoprim
800MG + 160MG
Aristo Pharmaceuticals Ltd.
| Pack size | 100's Pack |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 2.23 NPR |
Indications
TABROL-D.S. Tablet is used for:
UTI
Adult Dose
Oral
Urinary tract infections
Adult: Per tablet contains sulfadiazine 410 mg and trimethoprim 90 mg or per 5 mL suspension contains sulfadiazine 205 mg and trimethoprim 45 mg:
2 tablets or 20 mL as a single dose every 24 hr.
Child: >3 mth: Per day: 14 mg sulfadiazine/kg+3 mg trimethoprim/kg. Daily dose is divided into 2 equal doses given every 12 hr.
Child Dose
Oral
Urinary tract infections
Child: >3 mth: Per day: 14 mg sulfadiazine/kg+3 mg trimethoprim/kg.
Daily dose is divided into 2 equal doses given every 12 hr.
Renal Dose
Administration
Contra Indications
Hypersensitivity; severe renal/hepatic impairment; blood dyscrasias, porphyrias, serious hematological disorders; megaloblastic anemia secondary to folate depletion. Infants <2 mth; pregnancy (at term), lactation.
Precautions
Elderly, adequate fluid intake, G6PD deficiency, AIDS; actual or possible folate deficiency, child with fragile X chromosome associated with mental retardation; discontinue in case of skin rash; perform regular hematological examination.
Pregnancy-Lactation
Interactions
Sulphadiazine: Potentiates antidiabetic effect of sulphonylureas. Action antagonised by para-aminobenzoinc acid and procaine group of local anaesthetics.
Trimethoprim: Potentiate effects of phenytoin, digoxin, procainamide, warfarin. Reduces renal excretion of zalcitabine, zidovudine and lamivudine. Dapsone; rifampicin; increase risk of nephrotoxicity when given with cyclosporin; severe hyperkalaemia when given with ACE inhibitor; depressants of bone marrow function; risk of megaloblastic anemia with other folate inhibitors eg pyrimethamine, methotrexate; hyponatraemia if receiving diuretics concurrently.
Potentially Fatal: Potentiates oral anticoagulants, methotrexate and phenytoin. Ascorbic acid and hexamine may precipitate crystalluria; metabolism of oral hypoglycaemics may be inhibited.
Adverse Effects
Side effects of Sulphadiazine + Trimethoprim :
Nausea, vomiting, anorexia and diarrhoea. Hypersensitivity, skin reactions; lumbar pain, haematuria, oliguria, anuria, crystallisation in urine, thrombocytopaenia, leucopaenia, eosinophilia, neonatal jaundice and kernicterus.
Potentially Fatal: Stevens-Johnson syndrome; agranulocytosis, thrombocytopaenia, jaundice in new born. Mild GI disturbances; pruritus; skin rash; sulfonamide-like skin reactions; disturbances of liver enzyme values, cholestatic jaundice; raised serum creatinine and BUN; fever; anaphylaxis; aseptic meningitis; hematologic disturbances; photosensitivity; induce hyperkalemia particularly in HIV patients being treated for Pneumocystis carinii pneumonia or in the elderly.
Mechanism of Action
Sulphadiazine is a short-acting sulphonamide derivative with bacteriostatic action through competitive inhibition of bacterial synthesis of folic acid. Trimethoprim inhibits enzymes folic acid pathway, preventing the reaction of the dihydrolic acid to tetrahydrofolate.
Note
TABROL-D.S. 800MG + 160MG Tablet manufactured by Aristo Pharmaceuticals Ltd.. Its generic name is Sulphadiazine + Trimethoprim. TABROL-D.S. is availble in Nepal.
Farmaco Nepal drug index information on TABROL-D.S. Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.