Tacon Capsule
Itraconazole
100mg
Chemi Drug Industries Pvt. Ltd.
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 42.00 NPR |
Indications
Tacon Capsule is used for:
Candidiasis, Fungal infections, Tinea pedis, Tinea cruris, Tinea corporis, Pityriasis versicolor
Adult Dose
Oral
Adult: PO: Oropharyngeal candidiasis As cap: 100 mg/day for 15 days.
Vulvovaginal candidiasis As cap: 200 mg twice daily for 1 day.
Pityriasis versicolor As cap: 200 mg/day for 7 days.
Tinea corporis; Tinea cruris As cap: 100 mg/day for 15 days.
Fungal nail infections As cap: 200 mg/day for 3 mth.
Systemic fungal infections As cap: 100-200 mg once daily, up to 200 mg twice daily for invasive or disseminated infections.
Prophylaxis of infections in neutropenic or AIDS patients As cap: 200 mg/day, up to 200 mg twice daily if needed.
Tinea pedis; Tinea manuum As cap: 100 mg/day for 30 days or 200 mg bid for 7 days.
Child Dose
Child: PO 10 mg/kg/day, max 200 mg/day q12h
5 mg/kg/day for chronic mucocutaneous Candida q24h
<3 years: Safety and efficacy not established
Renal Dose
Administration
Should be taken with food. Take immediately after a full meal.
Contra Indications
Hypersensitivity to azole antifungals; pregnancy and lactation; hepatic disease. IV: CrCl: <30 ml/min.
Precautions
Renal insufficiency; CHF, history of CHF, COPD; monitor liver function.
Lactation: Drug enters breast milk; weigh risk against benefit
Pregnancy-Lactation
Interactions
May increase the plasma concentrations of oral anticoagulants, digoxin, cilostazol, alprazolam, midazolam (IV), repaglinide, corticosteroids (e.g. budesonide, dexamethasone, fluticasone, methylprednisolone). May increase plasma concentration w/ HIV protease inhibitors (e.g. ritonavir, indinavir, saquinavir), erythromycin, clarithromycin. May reduce plasma concentration w/ isoniazid, carbamazepine, nevirapine, phenytoin, Phenobarbital, rifampicin, rifabutin. May reduce absorption w/ PPIs, antacids, antimuscarinics, histamine H2 receptor antagonists. Concomitant use w/ dihydropyridines may cause oedema. May increase negative inotropic effects of verapamil. May increase risk of potentially fatal resp depression w/ fentanyl.
Potentially Fatal: May increase risk of QT prolongation or torsades de pointes w/ astemizole, bepridil, cisapride, dofetilide, levacetylmethadol (levomethadyl), mizolastine, pimozide, quinidine, sertindole, terfenadine, methadone, ranolazine, dronedarone, halofantrine. May increase risk of myopathy including rhabdomyolysis w/ HMG-CoA reductase inhibitors (e.g. atorvastatin, lovastatin, simvastatin). May increase risk of ergotism w/ ergot alkaloids (e.g. ergotamine, dihydroergotamine, ergometrine, methylergometrine). May potentiate hypnotic and sedative effect of triazolam and oral midazolam. May increase plasma concentration of eletriptan, nisoldipine, felodipine, disopyramide, irinotecan, lurasidone; colchicine (patient w/ renal or hepatic failure). May increase risk of hypotension and hyperkalaemia w/ eplerenone.
Adverse Effects
Side effects of Itraconazole :
>10%
Nausea (11%)
1-10%
Rash (9%),Vomiting (5%),Edema (4%),Headache (4%),Abnormal liver function test results (3%),Diarrhea (3%),Fever (3%),Hypertension (3%),Pruritus (3%),Fatigue (2-3%),Abdominal pain (2%),Dizziness (2%),Hypertriglyceridemia (2%),Hypokalemia (2%),Albuminuria (1%),Anorexia (1%),Decreased libido (1%),Hepatitis (1%),Malaise (1%)
Potentially Fatal: Liver failure; heart failure; pulmonary oedema; CV disease.
Mechanism of Action
Itraconazole decreases ergosterol synthesis by interfering w/ cytochrome P450 activity. This inhibits cell membrane function of susceptible fungi including Microsporum spp., Trichophyton spp., Candida spp., Aspergillus spp., Epidermophyton spp., Cryptococcus neoformans, Histoplasma capsulatum, Blastomyces dermatitidis, sporothrix schenckii, Malassezia furfur, Coccidioides immitis and Paracoccidiodes brasiliensis. It also has antiprotozoal activity against Leishmania spp.
Note
Tacon 100mg Capsule manufactured by Chemi Drug Industries Pvt. Ltd.. Its generic name is Itraconazole. Tacon is availble in Nepal.
Farmaco Nepal drug index information on Tacon Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.