Tenolol Tablet
Atenolol
100mg
Ipca Laboratories Ltd.
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Available as:
Indications
Tenolol Tablet is used for:
Hypertension, Migraine, Arrhythmias, MI, Angina pectoris
Adult Dose
Adult
Hypertension
25-50 mg/day PO initially; may be increased to 100 mg/day PO
Angina Pectoris
50 mg/day PO; after 1 week, may be increased to 100 mg/day PO; some patients may require 200 mg/day
Post Myocardial Infarction
Secondary prevention
100 mg PO once daily or divided q12hr for 6-9 days after myocardial infarction (MI)
Elderly
May be necessary to initiate dosing at 25 mg/day PO
Hypertension
25 mg/day PO initially; may be increased to 100 mg/day PO
Angina Pectoris
25 mg/day PO; after 1 week, may be increased to 100 mg/day; some patients may require 200 mg/day
Post Myocardial Infarction
Secondary prevention
100 mg PO once daily or divided q12hr for 6-9 days after MI
Child Dose
Renal Dose
Renal impairment:
CrCl (ml/min)
<15 25 mg or 50 mg on alternate days.
15-35 50 mg/day.
Dialysis patients 25-50 mg after each dialysis.
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity. Sinus bradycardia, sinus node dysfunction, heart block >1st degree, compensated cardiac failure, cardiogenic shock, bronchospastic diseases, peripheral vascular diseases. Pregnancy.
Precautions
Compensated heart failure. Variant angina, acute MI, DM; peripheral vascular disorders; hepatic and renal dysfunction; elderly patients, children. Lactation. If atenolol and clonidine are co-admin, then gradual withdrawal of clonidine should take place a few days after withdrawal of atenolol.
Lactation: Drug enters breast milk; neonates born to mothers who are receiving atenolol at parturition or breastfeeding may be at risk for hypoglycemia and bradycardia; use with caution
Pregnancy-Lactation
Interactions
Concomitant admin w/ reserpine may increase hypotension and bradycardia. Additive w/ Ca channel blockers, hydralazine, methyldopa. Increased risk of bradycardia and heart block w/ verapamil and diltiazem. May decrease hypotensive effects w/ NSAIDs (e.g. indometacin). Enhanced bradycardic effect w/ disopyramide, amiodarone or digitalis glycosides. May exacerbate rebound HTN upon discontinuance of clonidine treatment.
Adverse Effects
Side effects of Atenolol :
>10%
Tiredness (13%)
1-10%
Hypotension (10%),Bradycardia (8%),Cold extremities (0.5- 7%),Postural hypotension (2-4%),Depression (3%),Nausea (2-3%),Dreaming (2%),Drowsiness (2%),Diarrhea (1-2%),Fatigue (1-2%),Leg pain (1-2%),Lethargy (1-2%),Lightheadedness (1-2%),Vertigo (1-2%),Dyspnea (0.4-2%),2°/3° atrioventricular (AV) block (1%)
Frequency Not Defined
Hypotension, severe congestive heart failure (CHF), sick sinus syndrome, Catatonia, disorientation, emotional lability, hallucinations, headache, impaired performance on neuropsychometric tests, psychoses, short-term memory impairment, Purpura, rashes,Nausea, Thrombocytopenia, Elevated serum hepatic enzymes and bilirubin, Impotence, Peyronie disease, Antinuclear antibodies (ANA), lupus syndrome, Visual disturbances, xerophthalmia, Raynaud phenomenon
Potentially Fatal: Heart failure, 2nd or 3rd degree AV block.
Mechanism of Action
Atenolol is a competitive cardioselective beta1-blocker and does not have effect on ?beta2-receptors except in high doses. It reduces resting and exercise-induced heart rate as well as myocardial contractility.
Note
Tenolol 100mg Tablet manufactured by Ipca Laboratories Ltd.. Its generic name is Atenolol. Tenolol is availble in Nepal.
Farmaco Nepal drug index information on Tenolol Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.