Terafine Capsule
Terbinafine Topical
1% w/w
Biogain Remedies Pvt. Ltd.
| Pack size | 15g |
|---|---|
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Indications
Terafine Capsule is used for:
Tinea pedis, Tinea cruris, Tinea corporis, Dermatophytosis, Nail infections, Cutaneous candidiasis and Pityriasis versicolor
Adult Dose
Topical/Cutaneous
As cream or spray
Dermatophytosis
Adult:
Tinea Pedis: Apply to affected area BID until significant clinical improvement (no more than 4 weeks)
Tinea Corporis & Cruris: Apply once daily, for 1 week, (no more than 4 weeks)
Cutaneous candidiasis and pityriasis versicolor: Apply once or bid for 2 wk
Child Dose
Not FDA approved for peds
Renal Dose
Administration
Contra Indications
Hypersensitivity, active or chronic liver disease, lactation.
Precautions
Preexisting liver or renal impairment, pregnancy. Perform liver function tests prior to oral therapy.
Lactation: not safe for nursing infants
Pregnancy-Lactation
Interactions
Possible increase in levels in drugs metabolised by CYP450 2D6. Decreased terbinafine concentration with rifampicin; increased terbinafine concentration with cimetidine.
Adverse Effects
Side effects of Terbinafine Topical :
1-10%
Burning,Contact dermatitis,Dryness,Exfoliation,Irritation,Pruritus,Rash,Irritation,Stinging
Potentially Fatal: Liver failure, Stevens-Johnson syndrome, neutropaenia.
Mechanism of Action
Terbinafine causes fungal cell death by inhibiting squalene epoxidase, the main enzyme in sterol biosynthesis, resulting in ergosterol deficiency within fungal cell walls. It has fungicidal activity against dermatophytes and some yeast.
Note
Terafine 1% w/w Capsule manufactured by Biogain Remedies Pvt. Ltd.. Its generic name is Terbinafine Topical. Terafine is availble in Nepal.
Farmaco Nepal drug index information on Terafine Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.