Terbest 125 Tablet

Terbinafine Hydrochloride
125mg
Magnus Pharma Pvt. Ltd.
Pack size 1
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Indications

Terbest 125 Tablet is used for: Tinea pedis, Tinea cruris, Tinea corporis, Dermatophytosis, Nail infections

Adult Dose

Oral Onychomycosis Adult: 250 mg once daily for 6 weeks (fingernail) or 12 weeks (toenail) Tinea Pedis, Tinea Corporis, Tinea Cruris Adult: 250 mg/day PO in single dose or divided q12hr 2-4 wk in tinea cruris, tinea corporis 2-6 wk for tinea pedis Hepatic impairment: Use not recommended in chronic or active liver disease

Child Dose

Tinea Capitis >4 years (<25 kg): 125 mg/day PO for 6 weeks >4 years (25-35 kg): 187.5 mg/day PO for 6 weeks >4 years (>35 kg): 250 mg/day PO for 6 weeks

Renal Dose

Renal impairment: Use not recommended if CrCl <50 mL/min

Administration

May be taken with or without food.

Contra Indications

Hypersensitivity, active or chronic liver disease, lactation.

Precautions

Preexisting liver or renal impairment, pregnancy. Perform liver function tests prior to oral therapy. Lactation: Drug excreted in breast milk; do not use

Pregnancy-Lactation

Interactions

Possible increase in levels in drugs metabolised by CYP450 2D6. Decreased terbinafine concentration with rifampicin; increased terbinafine concentration with cimetidine.

Adverse Effects

Side effects of Terbinafine Hydrochloride : >10% Headache (13%) 1-10% Rash (6%),Pruritus (3%),Nausea (3%),Diarrhea (6%),Dyspepsia (4%),Abdominal pain (2%),Taste disturbance (3%),Elevated liver function test results (3%),Visual disturbance (1%) Potentially Fatal: Liver failure, Stevens-Johnson syndrome, neutropaenia.

Mechanism of Action

Terbinafine causes fungal cell death by inhibiting squalene epoxidase, the main enzyme in sterol biosynthesis, resulting in ergosterol deficiency within fungal cell walls. It has fungicidal activity against dermatophytes and some yeast.

Note

Terbest 125 125mg Tablet manufactured by Magnus Pharma Pvt. Ltd.. Its generic name is Terbinafine Hydrochloride. Terbest 125 is availble in Nepal. Farmaco Nepal drug index information on Terbest 125 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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