Terifrac Injection
Teriparatide
250mcg
Intas Pharmaceuticals Ltd.
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Indications
Terifrac Injection is used for:
Postmenopausal osteoporosis, Primary or hypogonadal osteoporosis in males
Adult Dose
Subcutaneous
Postmenopausal osteoporosis, Primary or hypogonadal osteoporosis in males
Adult: 20 mcg daily into the thigh or abdominal wall. Max treatment duration: 18 mth.
Child Dose
Renal Dose
Administration
Contra Indications
Patients at increased risk of osteosarcoma (e.g. Paget's disease of bone, unexplained increases in serum alkaline phosphatase, paediatric patients or young adults with open epiphyses and patients who have received prior external beam or implant radiation therapy involving the skeleton), pre-existing hypercalcaemia, bone metastases or a history of skeletal malignancies, severe renal impairment. Pregnancy and lactation.
Precautions
Moderate renal impairment, active or recent urolithiasis. Following SC inj, serum calcium concentrations may increase transiently, reaching a max at 4-6 hr and returning to baseline within 16-24 hr; routine calcium monitoring not needed. Patients to contact their doctor if they develop persistent symptoms of hypercalcaemia (e.g, nausea, vomiting, constipation, lethargy, muscle weakness).
Pregnancy-Lactation
Interactions
Reduced anabolic effects with bisphosphonates, avoid concurrent use. May affect digoxin effects due to teriparatide effects on calcum.
Adverse Effects
Side effects of Teriparatide :
Nausea, pain in the limb, headache, dizziness, muscle cramps, inj site reactions, depression, increased uric acid concentrations. Orthostatic hypotension especially at beginning of treatment, if affected, do not drive or operate machinery.
Mechanism of Action
Teriparatide, a biosynthetic peptide fragment of the biologically active region of the human parathyroid hormone, is a regulator of bone metabolism. By preferentially stimulating the osteoblastic activity over osteoclastic activity, it stimulates new bone formation on trabecular and cortical bone surfaces. Anabolic effects of teriparatide are seen in an increase in skeletal mass, bone strength and bone formation and resorption markers.
Note
Terifrac 250mcg Injection manufactured by Intas Pharmaceuticals Ltd.. Its generic name is Teriparatide. Terifrac is availble in Nepal.
Farmaco Nepal drug index information on Terifrac Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.