Terol LA 2 Tablet
Tolterodine Tartrate
2mg
Cipla Ltd.
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 15.05 NPR |
Available as:
Indications
Terol LA 2 Tablet is used for:
Overactive bladder
Adult Dose
Oral
Overactive Bladder, Urge Incontinence
Immediate release: 2 mg PO q12hr. Reduce to 1 mg bid if needed to reduce side effects.
Extended release: 2-4 mg PO once daily
Hepatic impairment
Mild to moderate (Child-Pugh class A or B): Not to exceed 1 mg PO q12hr (immediate release) or 2 mg PO once daily (extended release)
Severe (Child-Pugh class C): Not recommended
Child Dose
Child < 18 years: Not recommended
Renal Dose
Renal impairment
CrCl 10-30 mL/min: Not to exceed 1 mg PO q12hr (immediate release) or 2 mg PO once daily (extended release)
CrCl <10 mL/min: Not recommended
Administration
Contra Indications
Severe ulcerative colitis, toxic megacolon, urinary retention, gastric retention, myasthenia gravis, uncontrolled narrow-angle glaucoma, pregnancy.
Precautions
Bladder flow obstruction, GI obstructive disorders, renal or hepatic impairment, autonomic neuropathy, hiatus hernia, risk of decreased GI motility, patients at risk of QT interval prolongation (e.g. electrolyte disturbances, bradycardia, pre-exisiting cardiac disorder).
Lactation: Unknown whether drug is distributed in breast milk; do not nurse
Pregnancy-Lactation
Interactions
Increased risk of overdosage with potent CYP3A4 inhibitors e.g. macrolide antibiotics (erythromycin and clarithromycin), azole antifungals (e.g. ketoconazole and itraconazole), protease inhibitors, ciclosporin or vinblastine. Increased risk of torsade de pointes with drugs that prolong the QT interval (e.g. class Ia and class III antiarrhythmics). Increased risk of 'cholinergic neurogenic hypersensitivity' with centrally acting anticholinesterases (e.g. donepezil, rivastigmine). Increased risk of antimuscarinic side effects with antimuscarinic drugs.
Adverse Effects
Side effects of Tolterodine Tartrate :
>10%
Dry mouth (40%)
1-10%
Blurred vision,Constipation,Dizziness,Drowsiness,Dyspepsia,Headache,Xerophthalmia
Mechanism of Action
Tolterodine is a competitive muscarinic receptor antagonist with actions similar to atropine. It is used in the management of urge urinary incontinence, urgency and frequency.
Note
Terol LA 2 2mg Tablet manufactured by Cipla Ltd.. Its generic name is Tolterodine Tartrate. Terol LA 2 is availble in Nepal.
Farmaco Nepal drug index information on Terol LA 2 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.