Thalix Capsule
Thalidomide
100mg
Fresenius Kabi pharmaceuticals
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| Retail Price | 133.28 NPR |
Indications
Thalix Capsule is used for:
Multiple myeloma, Erythema nodosum leprosum
Adult Dose
Oral
Erythema nodosum leprosum (Type 2)
Adult: 100-300 mg once daily at bedtime, reduced gradually by 50 mg every 2-4 wk once a satisfactory reponse is achieved.
Not for monotherapy if moderate or severe neuritis present. Max: 400 mg/day. Patients < 50 kg: Initially, 100 mg daily.
Multiple myeloma
Adult: Initial dose of 200 mg once daily, increased by 100 mg at wkly intervals according to patient tolerance. Max: 800 mg daily.
Child Dose
Renal Dose
Administration
Should be taken on an empty stomach. Take on an empty stomach at least 1 hr after a meal, w/ a full glass of water.
Contra Indications
Hypersensitivity. Pregnancy and lactation.
Precautions
All females of childbearing potential must use 2 reliable forms of contraception simultaneously 4 wk before starting therapy, during and 4 wk after therapy is discontinued. Therapy to be stopped immediately if pregnancy occurs.
Male: Use of barrier methods of contraception if partner is of child-bearing potential. Do not donate blood or sperm during therapy. Patient should not drive or operate machinery. Discontinue therapy if any skin rash develops. Do not resume therapy if the rash is exfoliative, purpuric, or bullous, or if Stevens-Johnson syndrome or toxic epidermal necrolysis suspected.
Lactation: not known if excreted in breast milk, not recommended
Pregnancy-Lactation
Interactions
Thalidomide enhances sedative activity of barbiturates, alcohol, chlorpromazine and reserpine. Avoid use of other drugs that have the potential to cause peripheral neuropathy. Increased risk of thromboembolic events with darbepoetin-alfa and doxorubicin.
Potentially Fatal: Increased risk of bone marrow supression with peg interferon alfa.
Adverse Effects
Side effects of Thalidomide :
>10%
Somnolence (37%),Rash (21%),Edema (57%),Hypotension (16%),Leukopenia (17-35%),Neutropenia (31%),Increased bilirubin (14%),Myalgia (17%),Arthralgia (13%),Hematuria (11%),Thrombosis/embolism (23%),Headache (12%),Dyspnea (42%)
1-10%
Asthenia (8%),General pain (8%),Impotence (8%),Malaise (8%),Pruritus (8%),Xerostomia (8%),Flatulence (8%),Tooth pain (4%),Impotence (3-8%),Vertigo (8%),Constipation (4%),Diarrhea (4%),Neck rigidity (4%)
Frequency Not Defined
Photosensitivity,Bradycardia,Hypo/hypertension,Peripheral neuropathy,Neutropenia
Potentially Fatal: Stevens-Johnson syndrome, toxic epidermal necrolysis and blood dyscrasias.
Mechanism of Action
Thalidomide is a synthetic glutamic acid derivative immunomodulator with anti-inflammatory, antiangiogenetic, sedative and hypnotic activity.
Note
Thalix 100mg Capsule manufactured by Fresenius Kabi pharmaceuticals. Its generic name is Thalidomide. Thalix is availble in Nepal.
Farmaco Nepal drug index information on Thalix Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.