Tobraneg Injection
Tobramycin Sulphate
20mg
Elder Pharmaceuticals.
| Pack size | 2ml |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 45.50 NPR |
Available as:
Indications
Tobraneg Injection is used for:
Cystic fibrosis
Adult Dose
Inhalation
Cystic fibrosis
Indicated for management Pseudomonas aeruginosa in patients with cystic fibrosis
Adult: One single-use ampoule (300 mg) 12 hrly, inhaled from a suitable nebuliser for 28 days, then stop for 28 days and repeat in cycles of 28 days as needed.
Child Dose
Inhalation
Cystic fibrosis
Indicated for management Pseudomonas aeruginosa in patients with cystic fibrosis
Child: >6 yr : 300 mg 12 hrly, inhaled from a suitable nebuliser for 28 days, then stop for 28 days and repeat in cycles of 28 days as needed.
Renal Dose
Renal impairment: Dosage adjustment needed.
Administration
Contra Indications
Hypersensitivity to aminoglycosides; pregnancy.
Precautions
Preexisting renal and auditory or vestibular impairment; dehydration; neuromuscular blockade, muscular disorders (e.g. myasthenia gravis, parkinsonism); neonates; elderly; lactation.
Lactation: Unknown whether inhaled tobramycin will reach sufficient concentration to be distributed in breast milk; because of the potential for ototoxicity and nephrotoxicity in infants, a decision should be made whether to terminate breastfeeding or discontinue inhaled tobramycin
Pregnancy-Lactation
Interactions
Increased nephrotoxicity or ototoxicity with etacrynic acid, furosemide, other aminoglycosides, cefalotin, cisplatin, vancomycin, piperacillin, ciclosporin, amphotericin B. Decrease serum tobramycin levels with miconazole.
Potentially Fatal: Increased neuromuscular-blocking activity with magnesium and other neuromuscular-blocking agents.
Adverse Effects
Side effects of Tobramycin Sulphate :
>10%
Voice alteration (12.8%)
1-10%
Myalgia (4.7%),Laryngitis (4.3%),Tinnitus (3%),Epistaxis (3%)
Mechanism of Action
Tobramycin acts by binding to 30S ribosomal subunits thus interfering with bacterial protein synthesis. It is active against many aerobic gram-negative bacteria and some aerobic gram-positive bacteria but inactive against Chlamydia, fungi, viruses, and most anaerobic bacteria.
Note
Tobraneg 20mg Injection manufactured by Elder Pharmaceuticals.. Its generic name is Tobramycin Sulphate. Tobraneg is availble in Nepal.
Farmaco Nepal drug index information on Tobraneg Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.