Trazine S Tablet
Trifluoperazine + Trihexyphenidyl (Benzhexol)
5mg + 2mg
Sun Pharmaceutical Industries Ltd.
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Available as:
Indications
Trazine S Tablet is used for:
Used in the treatment of schizophrenia, Psychoses.
Adult Dose
Oral
Schizophrenia, Psychoses
Adult: 2–5 mg bid initially.
Maintenance: 15–20 mg/day in single or divided doses.
Few patients may require 40 mg/day.
Child Dose
Renal Dose
Administration
Administer at bedtime to minimize effects of sedation and orthostatic hypotension.
Should be taken with food.
Contra Indications
Hypersensitivity
Precautions
Preexisting CNS depression and coma; bone marrow depression, blood dyscrasias, liver disease, hypersensitivity to phenothiazines, prolactin dependent tumours. Pregnancy (1st trimester), lactation.
Avoid use of drug in children and adolescents with signs and symptoms suggestive of Reye's syndrome. Elderly, debilitated or emaciated patients: More susceptible to hypotensive and neuromuscular effects.
Special risk patients: Use drug with caution in patients with cardiovascular disease or mitral insufficiency, history of glaucoma, EEG abnormalities or seizure disorders, prior brain damage, hepatic or renal impairment.
CNS effects: Drug may impair mental or physical abilities, especially during first few days of therapy.
Hepatic effects: Jaundice usually occurs between second and fourth weeks of treatment and is considered hypersensitivity reaction. Usually reversible.
Pregnancy-Lactation
Interactions
Alcohol and other CNS depressants (eg, narcotics, sedatives): May result in increased CNS depression and may precipitate dystonic reactions.
Anticholinergics: May reduce therapeutic effects of trifluoperazine and worsen anticholinergic effects of trifluoperazine. May lead to tardive dyskinesia.
Barbiturate anesthetics: May increase frequency and severity of neuromuscular excitation and hypotension.
Guanethidine: May inhibit hypotensive action of guanethidine.
Metrizamide: Possibility of seizure may be increased when subarachnoid metrizamide injection is used.
Adverse Effects
Side effects of Trifluoperazine + Trihexyphenidyl (Benzhexol) :
Nausea, Constipation, Dryness in mouth, Sedation, Weight gain, Orthostatic hypotension (sudden lowering of blood pressure on standing), Urinary retention, Increased prolactin level in blood, Dizziness, Blurred vision, Nervousness
Mechanism of Action
Trifluoperazine inhibits dopamine D2 receptors in the brain. It has weak anticholinergic and sedative effects but strong extrapyramidal and antiemetic effects. It controls severely disturbed, agitated or violent behaviour but may also be used for nonpsychotic anxiety.
Trihexyphenidyl/Benzhexol is added to treat and prevent these side effects. Trihexyphenidyl HCl is a tertiary amine antimuscarinic which exerts a direct inhibitory effect on the parasympathetic nervous system. It also exhibits a direct spasmolytic action on smooth muscle, weak mydriatic, antisialagogue and cardiovagal blocking effects.
Note
Trazine S 5mg + 2mg Tablet manufactured by Sun Pharmaceutical Industries Ltd.. Its generic name is Trifluoperazine + Trihexyphenidyl (Benzhexol). Trazine S is availble in Nepal.
Farmaco Nepal drug index information on Trazine S Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.