Trental Tablet
Pentoxifylline
400mg
Aventis Pharma Limited.
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Indications
Trental Tablet is used for:
Peripheral vascular disease
Adult Dose
Oral
Peripheral vascular disease
Adult: As modified-release formulation: 400 mg tid (normally for at least 8 wk)
May reduce to 400 mg bid if GI or CNS adverse effects occur.
Intermittent Claudication
400 mg PO q8hr
Recommended duration of treatment: >8 weeks
Hepatic impairment: Dose reduction may be needed in severe impairment.
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment: Moderate impairment (CrCl about 60 ml/min): 400 mg bid;
Severe impairment (CrCl about 20 ml/min): 400 mg once daily; may reduce further to 400 mg once every other day if needed.
Administration
Should be taken with food.
Contra Indications
Previous hypersensitivity reactions to xanthine-related products e.g. caffeine, theophylline and theobromine. Recent cerebral and/or retinal haemorrhage. Porphyria.
Precautions
Avoid use in patients with severe cardiac arrhythmias or acute MI. Caution when used in patients with ischaemic heart disease or hypotension. Impaired renal or hepatic function. Start at lower dose in elderly; safety and efficacy not established in children. Tablets should not be chewed, crushed or broken; swallow whole. Pregnancy, lactation.
Lactation: Drug excreted in breast milk; discontinue therapy, or do not nurse
Pregnancy-Lactation
Interactions
Concurrent use with ciprofloxacin may increase the adverse effect of pentoxifylline. Concurrent use may increase serum levels of theophylline derivatives.
Potentially Fatal: May increase risk of adverse effect when used with ketorolac.
Adverse Effects
Side effects of Pentoxifylline :
1-10%
Nausea,Vomiting
<1%
Angina,Anaphylaxis,Anorexia,Aplastic anemia,Pancytopenia,Conjunctivitis,Angioedema,Aseptic meningitis,Chest pain,Leukemia,Leukopenia,Cholecystitis,Hepatitis,Seizure,Scotoma,Thrombocytopenia,Increased live enzyme
Potentially Fatal: Fatal haemorrhage (cerebral and GI tract); anaphylactoid reaction.
Mechanism of Action
Pentoxifylline reduces blood viscosity by increasing deformability of leukocytes and erythrocytes; and decreasing neutrophil adhesion/activation. It also improves microcirculation and peripheral tissue oxygenation through better blood flow. It has also been used in cerebrovascular disorders.
Note
Trental 400mg Tablet manufactured by Aventis Pharma Limited.. Its generic name is Pentoxifylline. Trental is availble in Nepal.
Farmaco Nepal drug index information on Trental Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.