Triple Antigen (DPT) Vaccine

Diphtheria + Tetanus + Pertussis Vaccine
0.5 ML
Serum Institute Of India Ltd
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Indications

Triple Antigen (DPT) Vaccine is used for: Active immunisation against diphtheria, tetanus and pertussis, Prophylaxis of tetanus in wound management

Adult Dose

Intramuscular Booster immunisation against diphtheria, tetanus and pertussis Adult: 0.5 mL via deep IM inj into the deltoid muscle of the upper arm, at least 5 years after last dose. Prophylaxis of tetanus in wound management Adult: In cases of uncertain or <3 doses of primary immunisation: 0.5 mL via deep IM inj into the deltoid muscle of the upper arm. In cases of >3 doses of primary immunisation: Administer 0.5 mL if >10 years since last dose for minor wounds or if >5 years since last dose for tetanus-prone wounds (e.g. contaminated with dirt, soil or faeces).

Child Dose

Intramuscular Active immunisation against diphtheria, tetanus and pertussis Child: >6 weeks to <7 years As primary immunisation: 1st-3rd doses: 0.5 mL at 2, 4 and 6 months of age at 4-8 weeks interval; 4th dose: 0.5 mL at approx 15-20 months of age, at least 6 months after 3rd dose; 5th dose: 0.5 mL at 4-6 years of age. Doses given via deep inj into the anterolateral muscles of the thigh (<6 weeks to <12 months of age) or the deltoid muscles of the upper arm (>12 months to <7 years of age). Booster immunisation against diphtheria, tetanus and pertussis Child: >10 years 0.5 mL via deep IM inj into the deltoid muscle of the upper arm, at least 5 years after last dose. Prophylaxis of tetanus in wound management Child: >10 years In cases of uncertain or <3 doses of primary immunisation: 0.5 mL via deep IM inj into the deltoid muscle of the upper arm. In cases of >3 doses of primary immunisation: Administer 0.5 mL if >10 years since last dose for minor wounds or if >5 years since last dose for tetanus-prone wounds (e.g. contaminated with dirt, soil or faeces).

Renal Dose

Administration

Contra Indications

Hypersensitivity. History of encephalopathy within 7 days with pertussis vaccine, progressive neurologic disorder (e.g. infantile spasms, uncontrolled or progressive epilepsy).

Precautions

Patient with history of Arthus-type hypersensitivity or Guillain-Barre syndrome with tetanus vaccine, bleeding disorders (e.g. thrombocytopenia), hypotonic-hyporesponsive episode or crying for ≥3 hours within 48 hours or seizures within 3 days with pertussis vaccine altered immunosuppression. Children (with personal or family history of seizures). Pregnancy and lactation. Postpone immunisation in patients with acute infection or severe febrile illness. Monitoring Parameters Monitor for anaphylaxis and signs of syncope for 15 minutes after inj.

Pregnancy-Lactation

Interactions

Decrease effect with immunosuppressive agents (e.g. corticosteroids, antimetabolites).

Adverse Effects

Side effects of Diphtheria + Tetanus + Pertussis Vaccine : Significant: Syncope, Guillain-Barre syndrome, brachial neuritis; apnoea (premature infants). Gastrointestinal disorders: Nausea, vomiting, diarrhea, abdominal pain. General disorders and administration site conditions: Asthenia, fatigue, malaise, fever, chills, inj site reactions (e.g. pain, oedema, erythema). Metabolism and nutrition disorders: Anorexia. Musculoskeletal and connective tissue disorders: Myalgia, arthralgia. Nervous system disorders: Headache, dizziness, somnolence. Psychiatric disorders: Irritability. Skin and subcutaneous tissue disorders: Rashes. Potentially Fatal: Hypersensitivity or anaphylaxis reaction.

Mechanism of Action

DTP vaccine, a combination of diphtheria and tetanus toxoids and acellular pertussis adsorbed vaccines, promotes immunity against diphtheria, tetanus and pertussis by inducing specific antibody production.

Note

Triple Antigen (DPT) 0.5 ML Vaccine manufactured by Serum Institute Of India Ltd. Its generic name is Diphtheria + Tetanus + Pertussis Vaccine. Triple Antigen (DPT) is availble in Nepal. Farmaco Nepal drug index information on Triple Antigen (DPT) Vaccine is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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