Tropan XL 5 Tablet
Oxybutynin Hydrochloride
5mg
Sun Pharmaceutical Industries Ltd.
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Available as:
Indications
Tropan XL 5 Tablet is used for:
Overactive bladder
Adult Dose
Oral
Overactive bladder
Adult: As extended-release preparation: Initially, 5 mg once daily increased by 5 mg every wk if necessary to max 30 mg daily.
Child Dose
Oral
Detrusor Overactivity, Nocturnal enuresis
Bladder overactivity associated with a neurologic condition (eg, spina bifida)
Child >6 years (extended-release): 5 mg/day PO initially; may be increased by 5 mg/day at weekly intervals; not to exceed 20 mg/day
Renal Dose
Administration
May be taken with or without food.
Contra Indications
GI obstruction or atrophy, severe toxic megacolon, significant bladder outflow obstruction, glaucoma, urinary retention.
Precautions
Elderly; hepatic or renal impairment; neuropathy; hyperthyroidism; prostatic hyperplasia; hiatus hernia; cardiac disease, reflux oesophagitis, ulcerative colitis, myasthenia gravis; pregnancy and lactation. High environmental temperature might cause heat prostration (fever with heat stroke due to decreased sweating).
Lactation: Unknown; use with caution
Pregnancy-Lactation
Interactions
Co-administration with other anticholinergic drugs may cause undesirable increased anticholinergic effects. Additive sedation with CNS depressants and alcohol. Concentration may be increased by CYP3A4 inhibitirs (e.g. imidazole antifungals, macrolide antibiotics).
Adverse Effects
Side effects of Oxybutynin Hydrochloride :
>10%
Dry mouth (21-71%),Constipation (7-15%),Somnolence (2-14%),Nausea (2-12%)
1-10%
Asthenia (6-10%),Dizziness (6-10%),Headache (6-10%),Blurred vision (6-10%),Dry eyes (6-10%),Diarrhea (6-10%),Nausea (6-10%),Pain (6-10%),Rhinitis (6-10%)
<1%
Anorexia,Fluid retention,Hot flush,Dysphonia,Dysphagia,Frequent bowel movements,Chest discomfort,Thirst
Frequency Not Defined
Cycloplegia,Impairment of mental alertness,Memory impairment,Mydriasis,Tachycardia,QT prolongation
Mechanism of Action
Oxybutynin exerts direct antispasmodic effect on the smooth muscle by inhibiting the muscarinic action of acetylcholine. It exhibits moderate anticholinergic effect, but has potent antispasmodic effects on urinary smooth muscle.
Note
Tropan XL 5 5mg Tablet manufactured by Sun Pharmaceutical Industries Ltd.. Its generic name is Oxybutynin Hydrochloride. Tropan XL 5 is availble in Nepal.
Farmaco Nepal drug index information on Tropan XL 5 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.