Trostigmin Tablet
Pyridostigmine
60mg
Troikaa Pharmaceuticals Ltd.
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Indications
Trostigmin Tablet is used for:
Reversal of neuromuscular blockade,Myasthenia gravis,Paralytic ileus and post-operative urinary retention
Adult Dose
Oral
Myasthenia gravis
Adult: 30-120 mg in divided doses, up to a total daily dose of 0.3-1.2 g.
Paralytic ileus and postoperative urinary retention
Adult: 60-240 mg daily.
Child Dose
Oral
Myasthenia gravis
Child: <6 yr Initially, 30 mg; 6-12 yr Initially, 60 mg. Doses are repeated throughout the day up to a usual total daily dose of 30-360 mg, w/ increments of 15-30 mg daily until a satisfactory response is obtained.
Paralytic ileus and postoperative urinary retention
Child: 15-60 mg daily.
Renal Dose
Renal impairment: Lower initial dose may be needed, titrate to desired effect.
Administration
Should be taken with food.
Contra Indications
Mechanical GI or urinary obstruction.
Precautions
Patient w/ bronchial asthma, COPD, bradycardia, cardiac arrhythmias, vagotonia, peptic ulcer, epilepsy or parkinsonism, hyperthyroidism. Renal impairment. Childn. Pregnancy and lactation. Monitoring Parameters Monitor cholinergic reaction particularly in IV admin.
Pregnancy-Lactation
Interactions
May exacerbate night vision problems w/ anti-glaucoma drugs. Antagonises the effect of non-depolarising muscle relaxants (e.g. pancuronium, vecuronium). Prolongs the effect of depolarising muscle relaxants (e.g. suxamethonium).
Adverse Effects
Side effects of Pyridostigmine :
Nausea, vomiting, diarrhoea, increased peristalsis and bronchial secretions, miosis, excessive salivation and sweating, abdominal cramps, bradycardia, bronchospasm, skin rash, muscle spasm, fasciculation, muscle weakness.
Potentially Fatal: Resp paralysis, cardiac arrest, pulmonary oedema.
Mechanism of Action
Pyridostigmine bromide facilitates impulse transmission across the myoneural junction by inhibiting the destruction of acetylcholine by acetylcholinesterase. It also has direct cholinomimetic effect on skeletal muscles.
Note
Trostigmin 60mg Tablet manufactured by Troikaa Pharmaceuticals Ltd.. Its generic name is Pyridostigmine. Trostigmin is availble in Nepal.
Farmaco Nepal drug index information on Trostigmin Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.