Unistrol 40 Tablet
Megestrol Acetate
40mg
United Biotech
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Indications
Unistrol 40 Tablet is used for:
Contraception, Breast carcinoma, Endometrial carcinoma, Anorexia and Cachexia
Adult Dose
Oral
Palliative treatment of breast carcinoma
Adult: 40 mg 4 times daily or 160 mg once daily.
Palliative treatment of endometrial carcinoma
Adult: 40-320 mg daily in divided doses. evaluate efficacy after 2 months of treatment; up to 800 mg/day may be used
Anorexia and cachexia in patients with cancer or AIDS
Adult: Initial: 800 mg daily. Usual range: 400-800 mg daily.
Child Dose
Renal Dose
Renal impairment: Use with caution; in normal renal function, 57-78% is excreted in urine within 10 days
Administration
Should be taken with food.
Contra Indications
Pregnancy and lactation. Severe hepatic impairment.
Precautions
History of thrombophlebitis, mild to moderate hepatic impairment, risk of fluid retention, history of depression, diabetes, hypertension, renal or cardiac dysfunction.
Lactation: Not safe; do not nurse
Pregnancy-Lactation
Interactions
Concentrations of indinavir may be reduced. Possible reduced efficacy of cisplatin. Warfarin half life may be increased. Megestrol concentration may be decreased by aminoglutethimide and enzyme-inducing drugs.
Adverse Effects
Side effects of Megestrol Acetate :
Common
Hypertension,Insomnia, mood swings
Rash, sweating,Amenorrhea, breakthrough bleeding, change in menstrual flow, hot sweats, impotence, spotting
Diarrhea, flatulence, indigestion, nausea, vomiting, weight gain
Serious
Deep vein thrombosis (DVT),Pulmonary embolism,Thrombophlebitis,Anemia,Adrenal insufficiency
Mechanism of Action
Megestrol is a progestogen used as an antineplastic and appetite stimulant. The mechanism of it's antineoplastic effects is not known but may be due to inhibition of oestrogen synthesis, modulation of other steroid hormones and/or a direct cytotoxic effect on tumour cells.
Note
Unistrol 40 40mg Tablet manufactured by United Biotech. Its generic name is Megestrol Acetate. Unistrol 40 is availble in Nepal.
Farmaco Nepal drug index information on Unistrol 40 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.