Valzaar 40 Tablet
Valsartan
40mg
Torrent Pharmaceuticals Ltd.
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 11.42 NPR |
Available as:
Indications
Valzaar 40 Tablet is used for:
Heart failure, Hypertension, Post myocardial infarction
Adult Dose
Oral
Hypertension
Adult: Initially, 80 mg once daily, may be increased to 160 mg once daily if needed. Max: 320 mg once daily.
Heart failure
Adult: Initially, 40 mg bid, may be increased to 160 mg bid if tolerated.
Post myocardial infarction
Adult: Start as early as 12 hr after MI in stable patients at an initial dose of 20 mg bid, doubled at intervals over a few wk up to 160 mg bid if tolerated.
Elderly: No dosage adjustment needed.
Hepatic impairment: Mild to moderate: Max: 80 mg once daily. Severe: Contraindicated.
Child Dose
Oral
Hypertension
Child: As tab: >6 yr <35 kg: Initially, 40 mg once daily. Max: 80 mg once daily;
35-80 kg: Initially, 80 mg once daily. Max: 160 mg once daily;
>80 kg: Initially, 80 mg once daily. Max: 320 mg once daily.
Renal Dose
Renal impairment
CrCl >30 mL/min: No dose adjustment necessary in adults
CrCl <30 mL/min: Use with caution in adults; not studied in children
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity; severe hepatic impairment, cirrhosis or biliary obstruction; primary hyperaldosteronism. Pregnancy (2nd and 3rd trimesters) and lactation.
Precautions
Patients w/ renal artery stenosis, heart failure, aortic or mitral stenosis, severe Na and/or volume depletion. Renal and mild to moderate hepatic impairment. Lactation. Monitoring Parameters Monitor BP, electrolytes, renal function. Monitor serum K levels every dose increment and periodically thereafter.
Pregnancy-Lactation
Interactions
May antagonise hypotensive effects and increase the risk of renal impairment w/ NSAIDs. Increased risk of hyperkalaemia w/ K-sparing diuretics, K supplements or K-containing salt substitutes.
Potentially Fatal: Increased risk of hypotension, hyperkalemia and changes in renal function (including acute renal failure) when used w/ aliskiren in patients w/ diabetes and renal impairment (GFR <60 mL/min).
Adverse Effects
Side effects of Valsartan :
>10%
Dizziness (17%; heart failure),Increased blood urea nitrogen (BUN; 17%)
1-10%
Hyperkalemia (4-10%),Dizziness (2-8%; hypertension),Hypotension (1-7%; heart failure),Fatigue (3%),Viral infection (3%),Neutropenia (2%),Syncope (>1%),Upper abdominal pain (>1%),Vertigo (>1%)
Frequency Not Defined
Headache,Cough (rare)
Potentially Fatal: Blood dyscrasias (e.g. neutropenia).
Mechanism of Action
Valsartan, an angiotensin II type 1 (AT1) receptor antagonist, produces its BP lowering effects by inhibiting angiotensin II-induced vasoconstriction, aldosterone release and renal reabsorption of Na.
Note
Valzaar 40 40mg Tablet manufactured by Torrent Pharmaceuticals Ltd.. Its generic name is Valsartan. Valzaar 40 is availble in Nepal.
Farmaco Nepal drug index information on Valzaar 40 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.