Ventiphylline Forte Tablet

Salbutamol + Theophylline
4mg + 200mg
Yash Pharma Laboratories Pvt. Ltd.
Pack size 10's
Dispensing mode
Source
Agent
Retail Price 1.55 NPR

Available as:

Indications

Ventiphylline Forte Tablet is used for: Chronic bronchitis; Emphysema; Asthma

Adult Dose

Oral Chronic bronchitis; Emphysema; Asthma Adult: Per tab contains salbutamol 2 mg and theophylline 100 mg: 1 or 2 tab 3-4 times daily.

Child Dose

Oral Chronic bronchitis; Emphysema; Asthma Child: Child (under 6 yrs) salbutamol (0.5-1mg) + theophylline (25-50mg) t.i.d/q.i.d. SR (S 4mg+T 300mg) 1 tab b.i.d.

Renal Dose

Administration

Contra Indications

Hypersensitivity, thyrotoxicosis.

Precautions

History of peptic ulcer and convulsive disorders, hepatic impairment, cardiac failure, hypertension, arrhythmias, diabetes mellitus,patients on MAOIs or tricyclic antidepressants, pulmonary oedema, hyperthyroidism, high fever, neonates and infants, pregnancy, lactation.

Pregnancy-Lactation

Interactions

Increased theophylline toxicity with propranolol, cimetidine, erythromycin (7-5 days), quinolone antibiotics. Reduced efficacy with rifampicin, phenobarbitone, phenytoin, carbamazepine, sulfinpyrazone and smoking. Increased risk of hypokalaemia with diuretics. Potentially Fatal: With anaesthetics, pancuronium bromide and sympathomimetics (increased risk of arrhythmias).

Adverse Effects

Side effects of Salbutamol + Theophylline : Seizures, tremor, muscle cramps, palpitation, hypokalaemia, headache, anorexia, nausea, anxiety, irritability, insomnia, rarely rash and angioedema. Potentially Fatal: Arrhythmias including premature ventricular contractions.

Mechanism of Action

Salbutamol is a selective beta2-agonist. It causes bronchial smooth muscle relaxation via the cyclic adenyl cyclase (cAMP) system. Theophylline is a phosphodiesterase inhibitor. It enhances intracellular cAMP conc thereby contributing to bronchial smooth muscle relaxation. It also suppresses airway hyper-response to stimuli. Advantage of this combination is the additive effect allowing reduction of individual doses.

Note

Ventiphylline Forte 4mg + 200mg Tablet manufactured by Yash Pharma Laboratories Pvt. Ltd.. Its generic name is Salbutamol + Theophylline. Ventiphylline Forte is availble in Nepal. Farmaco Nepal drug index information on Ventiphylline Forte Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Salbutamol + Theophylline :