Welmox 250 DT Tablet
Amoxicillin
250mg
Everest Pharmaceuticals Pvt. Ltd.
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Available as:
Indications
Welmox 250 DT Tablet is used for:
Bacterial infections,Pharyngitis,Acute otitis media,Acute bacterial sinusitis,Endocarditis,Anthrax,Chlamydial cervicitis,Chlamydial urethritis,Lyme disease,Dental abscess,Salmonellosis,Typhoid fever,Acute Uncomplicated gonorrhea,Infections of the Lower Respiratory Tract,Skin and Skin Structure,Genitourinary Tract,Ear,Nose,Throat
Adult Dose
Adult: PO Susceptible infections 250-500 mg 8 hrly. Uncomplicated gonorrhoea W/ probenecid: 3 g as a single dose. Dental abscesses 3 g, repeat once 8 hr later.
Uncomplicated acute UTI 3 g, repeat once 10-12 hr later. Prophylaxis of endocarditis 2 or 3 g as a single dose, 1 hr before dental procedure.
Severe or recurrent resp tract infections 3 g twice daily.
H.pylori infection W/ either metronidazole or clarithromycin and a bismuth compound or an antisecretory drug: 500 mg 3 times/day.
IV/IM Susceptible infections 500 mg 8 hrly. Listerial meningitis W/ other antibiotics: 2 g 4 hrly for 10-14 days.
Child Dose
Child: PO Standard dose: 40–45 mg/kg/day q8-12h
High dose: 80–90 mg/kg/day, max 4 g/day q12h
150 mg/kg/day div q8h for penicillin-resistant S pneumoniae otitis media
Renal Dose
Renal impairment: Patients on haemodialysis should receive 250-500 mg every 24 hr and an additional dose during and after each dialysis session.
CrCl (ml/min)
10-30 250-500 mg every 12 hr.
<10 250-500 mg every 24 hr.
Administration
May be taken with or without food. May be taken w/ meals for better absorption & to reduce GI discomfort.
Contra Indications
Hypersensitivity
Precautions
Renal and hepatic disease; pregnancy, lactation; infectious mononucleosis.
Lactation: Excreted in breast milk, use caution
Pregnancy-Lactation
Interactions
May reduce the efficacy of OC. May increase the effect of anticoagulants. Increased risk of allergic reactions w/ allopurinol. Increased and prolonged blood levels w/ probenecid. Chloramphenicol, macrolides, sulfonamides and tetracyclines may interfere w/ the bactericidal effect of amoxicillin.
Adverse Effects
Side effects of Amoxicillin :
Hyperactivity, agitation, insomnia, dizziness; maculopapular rash, exfoliative dermatitis, urticaria, hypersensitivity vasculitis; diarrhoea, nausea, vomiting; anaemia, thrombocytopenia, leucopenia, agranulocytosis.
Potentially Fatal: Neuromuscular hypersensitivity; pseudomembranous colitis.
Mechanism of Action
Amoxicillin inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall by binding to one or more of the penicillin-binding proteins (PBPs), thus inhibiting cell wall biosynthesis resulting in bacterial lysis.
Note
Welmox 250 250mg DT Tablet manufactured by Everest Pharmaceuticals Pvt. Ltd.. Its generic name is Amoxicillin. Welmox 250 is availble in Nepal.
Farmaco Nepal drug index information on Welmox 250 DT Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.