Xamdex Injection

Dexmedetomidine
100mcg
Abbott India Ltd.
Pack size
Dispensing mode
Source
Agent
Retail Price 701.63 NPR

Indications

Xamdex Injection is used for: ICU Sedation, Fiberoptic Intubation, Procedural Sedation

Adult Dose

ICU Sedation Load: 1 mcg/kg IV over 10 minutes Maintenance 0.2-1.4 mcg/kg/hr IV Titrate less frequently than q30min to prevent hypotension Fiberoptic Intubation Load: 1 mcg/kg IV over 10 minutes Maintenance 0.7 mcg/kg/hr IV Procedural Sedation Load: 1 mcg/kg IV over 10 minutes Maintenance 0.6 mcg/kg/hr IV titrate to effect (usually 0.2-1 mcg/kg/hr) Titrate less frequently than q30min to prevent hypotension Hepatic Impairment Dose reduction may be required

Child Dose

Safety and efficacy not established

Renal Dose

Renal Impairment Dose reduction may be required

Administration

IV Preparation Dilute in NS IV Administration Infuse loading dose over 10 min

Contra Indications

2nd or 3rd degree AV block (unless paced), uncontrolled hypotension, acute cerebrovascular disorders.

Precautions

Significant CV dysfunction, advanced heart block &/or severe ventricular dysfunction, hypovolemia, DM, chronic HTN. Renal & hepatic impairment. Do not inj by bolus or rapid IV. Do not administer for >24 hr. Pregnancy & lactation. Elderly. Childn <18 yr. Lactation: Excretion in milk unknown; use with caution

Pregnancy-Lactation

Interactions

Enhanced pharmacologic effects of anaesth, sedatives, hypnotics, opiate agonists, other vasodilators or drugs that have negative chronotropic effects (e.g. cardiac glycosides).

Adverse Effects

Side effects of Dexmedetomidine : >10% Hypotension (28%) 1-10% AFib.Anemia,Bradycardia,Fever,Pleural effusion,Leukocytosis,Pulmonary edema

Mechanism of Action

Centrally acting alpha2-adrenoceptor agonist that has sedative and anesthetic properties possibly by activating G-proteins in the brainstem, which results in the inhibition of norepinephrine release.

Note

Xamdex 100mcg Injection manufactured by Abbott India Ltd.. Its generic name is Dexmedetomidine. Xamdex is availble in Nepal. Farmaco Nepal drug index information on Xamdex Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Dexmedetomidine :