Xamic Tablet

Tranexamic Acid
500mg
Torrent Pharmaceuticals Ltd.
Pack size 100's
Dispensing mode
Source
Agent
Retail Price 27.38 NPR

Available as:

Indications

Xamic Tablet is used for: Haemorrhage, Hereditary angioedema

Adult Dose

Oral Short-term management of haemorrhage Adult: 1-1.5 g or 15-25 mg/kg bid or tid. Management of hereditary angioedema Adult: 1-1.5 g bid or tid. Intravenous Short-term management of haemorrhage Adult: 0.5-1 g or 10 mg/kg tid or 25-50 mg/kg daily by continuous infusion.

Child Dose

Oral Short-term management of haemorrhage Child: 25 mg/kg bid or tid. Management of hereditary angioedema Child: 25 mg/kg bid or tid. Intravenous Short-term management of haemorrhage Child: 10 mg/kg bid or tid.

Renal Dose

Renal impairment: Adjust dose based on serum creatinine concentration: 120-250 micromol/l: 15 mg/kg bid daily; 250-500 micromol/l: 15 mg/kg once daily; >500 micromol/l: 7.5 mg/kg once daily or 15 mg/kg once every 48 hr.

Administration

May be taken with or without food.

Contra Indications

Severe renal failure, active intravascular clotting, thromboembolic disease, colour vision disorders, subarachnoid bleeding.

Precautions

Mild to moderate renal impairment, irregular menstrual bleeding, previous history of thromboembolic disease, haematuria. Monitor closely in disseminated intravascular coagulation. Monitor LFT and eye examination regularly during long-term use. Discontinue if disturbance in colour vision occurs. Avoid IV inj rate >1 ml/minute due to risk of hypotension. Pregnancy, lactation.

Pregnancy-Lactation

Interactions

Potentially Fatal: Increased risk of thrombus formation with estrogens, Factor IX complex concentrates or anti-inhibitor coagulant concentrates. Increased risk of fatal thrombotic complications with tretinoin in acute promyelocytic leukaemia.

Adverse Effects

Side effects of Tranexamic Acid : >10% Headache (50.4%),Nasal and sinus symptoms (25.4%),Back pain (20.7%),Abdominal pain (19.8%),Musculoskeletal pain (11.2%) 1-10% Arthralgia (6.9%),Muscle cramps and spasms (5.8%),Migraine (6%),Anemia (5.6%),Fatigue (5.2%) Frequency Not Defined Visual abnormalities,Hypotension (with rapid injection),Nausea,Vomiting,Diarrhea

Mechanism of Action

Tranexamic acid is an antifibrinolytic agent that competitively inhibits breakdown of fibrin clots. It blocks binding of plasminogen and plasmin to fibrin, thereby preventing haemostatic plug dissolution.

Note

Xamic 500mg Tablet manufactured by Torrent Pharmaceuticals Ltd.. Its generic name is Tranexamic Acid. Xamic is availble in Nepal. Farmaco Nepal drug index information on Xamic Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Tranexamic Acid :