Xefclor Capsule
Cefaclor
250mg
Deurali Janta Pharmaceuticals Pvt. Ltd.
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| Retail Price | 35.00 NPR |
Indications
Xefclor Capsule is used for:
Pneumonia, Meningitis, Peritonitis, Otitis media, Septicaemia, Biliary-tract infections, Urinary-tract infections, Skin and skin structure infections, Upper and lower respiratory tract infections, Pharyngitis and Tonsillitis
Adult Dose
Oral
Urinary tract infections, Upper and lower respiratory tract infections, Skin infections, Otitis media
Adult: As monohydrate: 250-500 mg every 8 hr. Max: 4 g daily.
Child Dose
Oral
Urinary tract infections, Upper and lower respiratory tract infections, Skin infections, Otitis media
Child: PO 20–40 mg/kg/day, max 1 g/day q12h
1-5 yr: 125 mg tid,
>5 yr: 250 mg tid.
Suspension & Paediatric Drops:
1 month - 1 year 2.5 ml t.i.d. 0.625 ml t.i.d
1 year - 5 year 5 ml t.i.d. 1.25 ml t.i.d
over 5 years 10 ml t.i.d 2.5 ml t.i.d
Renal Dose
Renal Impairment
CrCl: 10-50 mL/min: Half to full dose
CrCl: <10 mL/min: Half dose
Administration
May be taken with or without food.
Contra Indications
Known hypersensitivity to cephalosporins.
Precautions
Severe renal impairment; history of allergy to penicillin; pregnancy, lactation.
Lactation: enters breast milk; use with caution
Pregnancy-Lactation
Interactions
May enhance the nephrotoxic effect of aminoglycosides. May diminish the therapeutic effect of BCG, typhoid vaccine and Na picosulfate. Concomitant use w/ warfarin may increase prothrombin time. Probenecid inhibits renal excretion of cefaclor.
Adverse Effects
Side effects of Cefaclor :
1-10%
Diarrhea (3%),Increased transaminases (3%),Eosinophilia (2%),Moniliasis (2%),Vaginitis (2%),Rash (maculopapular, erythematous, or morbiliform) (1-2%)
<1%
Stevens-Johnson syndrome,Pseudomembranous colitis,Nausea,Vomiting,Anemia,Neutropenia,Jaundice
Potentially Fatal: Anaphylactic reaction; pseudomembranous colitis.
Mechanism of Action
Cefaclor binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. It has bactericidal activity against gm-ve bacteria including E. coli, S. pneumoniae, N. gonorrhoea, P. mirabilis and H. influenzae.
Note
Xefclor 250mg Capsule manufactured by Deurali Janta Pharmaceuticals Pvt. Ltd.. Its generic name is Cefaclor. Xefclor is availble in Nepal.
Farmaco Nepal drug index information on Xefclor Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.