Xenith Suspension

Albendazole
200mg
Mapra Laboratories Pvt Ltd.
Pack size 10ml
Dispensing mode
Source
Agent
Retail Price 17.88 NPR

Available as:

Indications

Xenith Suspension is used for: Helminthiasis, Echinococcosis, Neurocysticercosis, Enterobiasis, Ascariasis, Hookworm infections, Strongyloidiasis, Giardiasis, Filariasis

Adult Dose

Echinococcosis Adult: <60 kg: 15 mg/kg daily in 2 divided doses. Max: 800 mg/day. ?60 kg: 400 mg bid. Admin dose for three 28-day cycles w/ a 14-day drug-free interval in between each cycle. Neurocysticercosis Adult: <60 kg: 15 mg/kg daily in 2 divided doses (max: 800 mg/day) for 8-30 days. ?60 kg: 400 mg bid for 8-30 days. Ancylostoma, Ascariasis, Hookworm, Trichostrongylus 400 mg PO once

Child Dose

Child: PO 15 mg/kg/day (max 800 mg/day) q12h

Renal Dose

Administration

Should be taken with food.

Contra Indications

Pregnancy and lactation. Neonates. Hypersensitivity, liver impairment.

Precautions

Monitor blood counts and liver function. Administer within 7 days of start of normal menstruation in women of childbearing age. Adequate nonhormonal contraceptive measures must be taken during and for 1 mth after therapy. Perform liver function tests and blood counts before and every 2 wk during high dose therapy of hydatid disease. Lactation: unknown, use caution.

Pregnancy-Lactation

Interactions

Increased serum concentrations w/ dexamethasone, praziquantel and cimetidine. Decreased serum concentrations w/ aminoquinoline (antimalarials), carbamazepine, phenobarbital, and phenytoin.

Adverse Effects

Side effects of Albendazole : >10% Headache,Neurocysticercosis (11%),Hydatid disease (1.3%),Abnormal LFT,Hydatid disease (15.6%),Neurocysticercosis (<1%) 1-10% Abdominal pain,Hydatid disease (6%),Nausea/vomiting,Hydatid disease (3.7%),Neurocysticercosis (6.2%),Dizziness/vertigo,Hydatid disease (1.2%),Neurocysticercosis (<1%),Increased intracranial pressure,Neurocysticercosis (1%),Meningeal signs,Neurocysticercosis (1%),Alopecia (reversible),Hydatid disease (1.6%),Neurocysticercosis (<1%),Fever,Hydatid disease (1%) <1% (selected) Rash,Urticaria,Agranulocytosis,Aplastic anemia,Bone marrow suppression,Granulocytopenia,Pancytopenia,Thrombocytopenia,Hepatitis,Acute liver failure,Acute renal failure Potentially Fatal: Bone marrow depression.

Mechanism of Action

Albendazole sulfoxide (active metabolite), causes selective degeneration of cytoplasmic microtubules in intestinal and tegmental cells of intestinal helminths and larvae; glycogen is depleted, glucose uptake and cholinesterase secretion are impaired and desecratory substances accumulate intracellulary. ATP production decreases, causing energy depletion, immobilisation and worm death.

Note

Xenith 200mg Suspension manufactured by Mapra Laboratories Pvt Ltd.. Its generic name is Albendazole. Xenith is availble in Nepal. Farmaco Nepal drug index information on Xenith Suspension is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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